Figure 7 : Schematic of proposed molecular mechanism linking SPL activity, synaptic transmission and cognitive skills.

From: Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism

Figure 7

S1P accumulation upon SPL deletion causes elevation of cytosolic Ca2+, which in turn increases the activity of the ubiquitin-proteasomal system (UPS). As a consequence the expression of the proteasome-associated deubiquitinating enzyme USP14 and of some presynaptic proteins is reduced, thereby impairing presynaptic plasticity coupled to behavioural and motor coordination deficits. PPF, paired pulse facilitation; SV, synaptic vesicle.