Figure 8 : The model can account for 180 degree shift in the PC activity and eye movement impairment in IO-ΔRobo3 mice during VOR.

From: Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments

Figure 8

(a) Schematic illustration of the altered olivocerebellar circuitry in IO-ΔRobo3 mice. For the wildtype schematics and abbreviations see Fig. 1a. Note that the climbing fibers (CF, purple) project to the PCs on the ipsilateral side. (b, top) Representative PSTHs of SS and CS activity from in vivo recording during VOR stimulation as a function of time in the cycle in IO-ΔRobo3 (purple) and littermate controls (black). (b, bottom) SS and CS activity predicted by the model with ipsilateral projecting CFs (purple) and controls (black dashed line). Note that the peak of the modulation is reversed with respect to the wild type mice, which is consistent with experimental data (raw experimental data obtained from: Badura et al.22). (c) Gain and phase values of the eye movements during VOR (0.6 Hz) in naïve wild type (black) and IO-ΔRobo3 (purple) mice. Error bars denote SD; *denote p < 0.05; **denote p < 0.001.