Figure 7 : Silencing majority of granule cells prevents the model from learning the VOR phase-reversal.

From: Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments

Figure 7

(a) Part of cerebellar circuitry shown in Fig. 1a; Red “X” symbols indicate loss of signal transmission from GCs. (b) Experimental and modeled eye movements in GC-ΔCACNA1A mice as a function of training time of VOR phase-reversal training. Gain values (top panel) are normalized to the initial gain. Experimental data represent averages with SEM (green shaded area) and SD (grey shaded area) of the GC-ΔCACNA1A mice. Grey dotted line indicates the values of the littermate controls. Note that the modeled values (red) are locked at the gain of 1 and phase of 0 due to the blockage of the potentiation at the PF-PC synapse. (c) Representative PSTHs from in vivo recording from naive GC-ΔCACNA1A mice, in which GC output is reduced by ~75% during VOR stimulation (0.6 Hz). (d) Polar plot of SS and CS responses to VOR stimulation in naïve GC-ΔCACNA1A mice. Each dot represents one cell. Phase of the modeled SS and CS are indicated with the arrows. (e) Modulation of SS, is attenuated in GC-ΔCACNA1A mice. Error bars denote SD. (f) In our model the effect of reducing GC output by 75% and blocking PF-PC long–term plasticity is in line with the experimental data, in that the modulation depth of simple-spikes in Purkinje cells of GC-ΔCACNA1A mice is also significantly reduced during VOR.