Figure 1 : Cerebellar circuitry and experimental design.

From: Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments

Figure 1

(a) Organization of a basic cerebellar module of the oculomotor pathway. Vestibular input to the vestibular nucleus (VN) carries the signal about the head movement (mossy fibers, black). This signal is also relayed by mossy fibers onto granule cells (GC, green), which innervate Purkinje cells (PC, black). The inferior olive (IO) receives information about the retinal slip that is first processed by the accessory optic system (AOS). The IO neurons innervate the contralateral PCs through climbing fibers (CF; purple). Those two inputs converge on PCs, which send their output back to VN, forming a loop. This loop is modulated by an inhibitory side loop represented by molecular layer interneurons (MLIs, blue). The magenta circles and +/− signs indicate sites of plasticity incorporated in the model. (b) Schematic representation of vestibulo-ocular response (VOR) phase-reversal adaptation. During the learning, a mouse is headfixed on a turntable and phase adaptation is achieved by an in-phase table and drum rotation in the light. With each of the five training sessions there is an increase in amplitude of the drum rotation, but the oscillation frequency of the turntable remains fixed at 0.6 Hz. Note that by the end of day five the phase of eye movements of a mouse is reversed so that the eye movements are now in-phase with the rotation of the turntable.