Figure 4

From: Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

Figure 4

Binding of anti-Aβ antibody (10D5, Eli Lilly, (A)), 5 (B), and thioflavin S (C) to Aβ plaques in AD brain near/adjacent tissue sections. Amyloid in postmortem frontal lobe of a 90-year-old male. Magnification: 200X. (A): diffuse Aβ plaques and an arteriole with Aβ deposits (cerebral amyloid angiopathy); 10D5 immunohistochemistry. (B): section stained with 5 containing the same arteriole as in (A). There are numerous diffuse Aβ plaques (arrows) and compact plaques (arrow head) and the vessel is also stained. (C): Thioflavin S reveals amyloid in blood vessels and compact plaques (arrow head). The same blood vessel (asterisk) is labeled in (AC). Similar results were obtained with more than three independent experiments.