Conditional association analysis at the novel gene loci for height, BMI and schizophrenia.
In the analysis of the latest GWAS data for height, BMI and schizophrenia, there are 5 genes loci at which the signal from fastBAT is orders of magnitude higher than the top associated SNP from GWAS, suggesting there are multiple independent causal variants in these regions. Shown are the results from the GCTA condition analysis using the 1KGP-imputed HRS data as the reference for LD estimation (Methods). Shown in red are the original GWAS results, in green are the results from the conditional analysis conditioning on the top SNP (labeled as ‘Cond round 1’), and in blue are the results from the conditional analysis conditioning on the top two independent signals (‘Cond round 2’). The blue horizontal line represents the threshold p-value of 5 × 10−8.