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Figure 1

From: Distinct Genetic Influences on Cortical and Subcortical Brain Structures

Figure 1

The path diagram for the univariate ACE twin model (A) and Independent Pathway Model (IPM) for estimating the overlap between the two hemispheres (L ROI and R ROI) for each of the brain structures (B). (A) The brain volumetrics of the twin 1 and twin 2 are modelled as the function of the mean parameter (M) and the additive genetic (A), shared environmental (C) and unique environmental (E) factors. The path coefficients a, c and e are the estimated loadings of the latent factors and the variance components corresponding to the factors (E) are respectively denoted as , .and . The parameter (ra = 1 for MZ twin pairs and ra = 0.5 for DZ twin pairs) and rc (ra = 1 for both MZ and DZ twin pairs) respectively denote the additive genetic and shared environmental correlation between the twin pairs (B). IPM for one of the twins shown here. Additive genetic (A), shared environmental (C), and unique environmental (E) factors; subscript c and s refer respectively to common and specific genetic components of the L (left) and R (right) regions of interest (ROIs). The model is identifiable under the constraint (ac1 = ac2; cc1 = cc2; ec1 = ec2).

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