Figure 6 | Scientific Reports

Figure 6

From: TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

Figure 6

Hypothetic model for IL-1β–IL-1RI-mediatede AM Pyroptosis and Lung Inflammation in response to LPS.

In AM LPS-TLR4 signaling not only activates Nlrp3 inflammasome activation and subsequent release of IL-1β, but also up-regulates IL-1RI cell surface expression through MyD88 and NF-κB dependent signaling. The upregulated IL-1RI, therefore, sensitizes AM to IL-1β and results in pyroptosome activation, which in turn leads to AM pyroptosis, a type of caspase-1-dependent inflammatory cell death and subsequent exaggerated lung inflammation.

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