Figure 4: Schematic representation of our model. | Scientific Reports

Figure 4: Schematic representation of our model.

From: Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development

Figure 4

HDAC1 is phosphorylated by Aurora kinases A and B during prophase. The Aurora-dependent phosphorylation of HDAC1 decreases its deacetylating activity thus enhancing the expression of a subset of genes in developing zebrafish embryos and is crucial for normal development. The timely dephosphorylation of HDAC1 is required to bring the expression of target genes back to basal levels and ensure the proper progression of the cell cycle (cell cycle progression). TSS: Transcription Start Site.

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