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Figure 1

From: In vivo and in vitro protective effects of omeprazole against neuropathic pain

Figure 1

Omeprazole ameliorated the cold, warm and mechanical stimuli induced allodynia in CCI induced neuropathic pain in rats.

(A) In cold allodynia treatment with omeprazole (50 mg/kg p.o. for 14 days) showed time dependent increase in the paw withdrawal latency in CCI control rats without influencing the measures in sham rats. (B) In warm allodynia treatment with omeprazole (50 mg/kg p.o. for 14 days) showed time dependent increase in the paw withdrawal latency and threshold in CCI-control rats but not in sham rats. (C) In Mechanical allodynia, treatment with omeprazole (50 mg/kg p.o. for 14 days) showed time dependent increase in the paw withdrawal latency or threshold in CCI-control rats but not in sham rats. Data are expressed as the mean ± S.E.M. (n = 8/group). Significance was determined by repeated measures ANOVA followed by the Dennett’s post-hoc test. The statistical significance of difference of CCI-control compared to sham was shown as ###p < 0.001, whereas the statistical significance of difference in the omeprazole and gabapentin treated groups as compared to CCI-control was designated as ***p < 0.001.

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