Figure 5 : Graphical representation for the hBM-MSCs Secretome (i.e. CM) classical trophic factors by Bioplex analysis.

From: Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation

Figure 5

Comparative analysis showed an upregulation in the concentration levels of (A) brain-derived neurotrophic factor (BDNF), (B) vascular endothelial growth factor (VEGF), (C) nerve growth factor (NGF), (D) insulin growth factor 1 (IGF-1) and (E) miR-16 in the hMSC dynamic CM when compared to the static condition. Trophic factor values were normalized to cell density (i.e. pg (of each factor)) per 10,000 cells in each condition, respectively. CMs: hBM-MSCs static conditioned media. CMd: hBM-MSCs dynamic conditioned media. Values are shown as mean ± SEM, n = 3; ***p < 0.001.

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