Figure 1 | Scientific Reports

Figure 1

From: Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′,5′difluorophenyl)-alanine

Figure 1

Sequences of Somatostatin and Octreotide and of the six Somatostatin analogs synthesized in this work.

For simplicity, the disulfide bridge present in these molecules is displayed only on the top of the Somatostatin and Octreotide sequences. The modified amino acids are depicted as colored rectangles, yellow for D-Trp, blue for L-Dfp, red for L-Msa, gray for D-Phe and purple for L-Thr-ol. The pharmacophore region of the native hormone and of all analogs is highlighted in green.

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