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Control mice (CTR) and C26-bearing mice (C26) were kept in wheel-equipped cages and performed 19 days of voluntary wheel-running (WR) activity, which was individually recorded. *parameter values are based on the last five days, which correspond to a plateau phase of exercise activity and to overt cachexia in C26-bearing mice. The means ± SEM are shown. Tumor-bearing mice perform voluntary wheel running even in advanced stages of the disease.