Figure 1 : Voluntary wheel running counteracts cancer cachexia and prolongs survival of tumor-bearing mice.

From: Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

Figure 1

(a) TA muscle weight of C26-bearing mice in the absence (—) or presence (WR) of voluntary wheel running for 19 days. WR rescues muscle mass of C26-bearing mice. Data are shown as mean ± SEM; 6 < n < 9 for each group, *p < 0.05 by Student’s t-test. (b) Representative immunostaining for laminin on TA muscle of C26-bearing mice in the absence (—) or presence (WR) of wheel running for 19 days, showing that WR increases fiber size and improves basement membrane morphology in C26-bearing mice. Scale bar = 100 microns. (c) Median ± SEM of glycolytic TA myofiber cross-sectional area of C26-bearing mice in the absence (—) or presence (WR) of wheel running for 19 days. WR rescues fiber size of C26-bearing mice. n = 5 for each group, *p < 0.05 by Student’s t-test. (d) Fatigue time of EDL muscle of control or C26-bearing mice in the absence (—) or presence (WR) of wheel running for 19 days. Data are shown as mean ± SEM. Two-way ANOVA (F = 5.77; df 1; p = 0.025) shows an interaction between the negative effect of C26 tumor and wheel running, which restores fatigue time to control levels; data are shown as mean ± SEM; 6 < n < 9 for each group, *p < 0.05 by Tukey’s HSD test. (e) Survival curves derived from Cox model for statistical analysis of C26-bearing mice in the absence (C26, circles) or presence (C26 WR, triangles) of wheel running. Wheel running significantly (p < 0.041) increased survival of C26-bearing mice. n = 9 for each group. (f) Linear correlation between running distance (Km per day) and life span (days of survival) in C26-bearing mice. From the curve equation, one can infer that each km/day of wheel running corresponds to an increase of approximately 4 days in life span.