Figure 5 : Sustained endothelial Wnt/β-catenin signaling and heart failure.

From: Activation of endothelial β-catenin signaling induces heart failure

Figure 5

Expression of degradation-resistant β-catenin (Δex3) activated Wnt/β-catenin signaling and suppressed the expression/secretion of neuregulin-1 in/from endothelial cells. Low neuregulin level suppressed cardiac ErbB signaling and promoted cardiac dysfunction.