Figure 2 | Scientific Reports

Figure 2

From: Effects of hydrogen-rich water on depressive-like behavior in mice

Figure 2

IL-1β level in hippocampus and cortex.

(a) IL-1β levels in hippocampi of stress group mice increased significantly when compared to the control group (F1, 16 = 31.12, P < 0.0001, post hoc ***P < 0.0001, n = 5, 5, 5, 5) and compared to the hydrogen-rich water group (F1, 16 = 21.88, P = 0.0003, post hoc ***P < 0.0001, n = 5, 5, 5, 5). The hydrogen-rich water hindered the stress-induced increasing of IL-1β levels in hippocampi as shown in the comparison between hydrogen-rich water + stress group and stress group (F1, 16 = 21.88, P = 0.0003, post hoc ***P < 0.0001, n = 5, 5, 5, 5). (b) IL-1β levels in cortexes of stress group mice increased significantly when compared to the control group (F1, 16 = 27.70, P < 0.0001, post hoc ***P < 0.0001, n = 5, 5, 5, 5) and compared to the hydrogen-rich water group (F1, 16 = 14.27, P = 0.0016, post hoc ***P < 0.0001, **P < 0.001, n = 5, 5, 5, 5). The hydrogen-rich water inhibited the stress-induced increasing of IL-1β levels in cortexes as shown in the comparison between hydrogen-rich water + stress group and stress group (F1, 16 = 14.27, P = 0.0016, post hoc ***P < 0.0001, **P < 0.001, n = 5, 5, 5, 5). No significant differences observed among the control, hydrogen-rich water and hydrogen-rich water + stress groups. Data was analyzed using a two-way ANOVA followed by the Bonferroni’s multiple comparisons post hoc test. Error bars represent s.e.m.

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