Figure 4 | Scientific Reports

Figure 4

From: Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions

Figure 4

Sequence patterning synergies between the T-cell autoimmune epitopes and aggregation prone regions.

Sequence logos are shown for (a) 100,000 randomly generated 15-residues long peptides, (b) 83,616 random peptides that were not predicted to be T-cell autoimmune epitopes (non-epitopes), (c) 16,384 strongly predicted T-cell autoimmune epitopes, (d) 12,179 random peptides that contain TANGO predicted APRs, (e) 8,559 non-epitopes that contain TANGO APRs, (f) 3,620 T-cell autoimmune epitopes that contain TANGO APRs, (g) 9,582 random peptides that contain WALTZ predicted APRs, (h) 7,261 non-epitopes that contain WALTZ APRs and (i) 2,331 T-cell autoimmune epitopes that contain WALTZ APRs. Note the enrichment of hydrophobic β-branched and aromatic residues, particularly Val, Ile and Phe, at initial positions of T-cell autoimmune epitope peptides (see panels c,f,i).

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