Figure 8 : TREM2+ IBA1+ microglia/monocytes increase after chronic consumption of a western diet in both B6 and B6.APBTg mice.

From: Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

Figure 8

(AC) TREM2+ (green) microglia/monocytes (IBA1+, red) increase within the hippocampus of B6 mice fed the western diet (B) compared to the control died (A). The total number TREM2 expressing IBA1+ cells are significantly increased (p = 0.001, n = 4, C). (DG) TREM2+ IBA1+ cells also significantly increase within the hippocampus of B6.APBTg mice fed the western diet (B,D) compared to the control died (A,C) (p = 0.0006, n = 4, H). (I) There is a strong correlation between the number of TREM2+ IBA1+ microglia/monocytes and the number of amyloid-β plaques in the hippocampus (p = 0.0035, R2 = 0.8432, n = 4). Blue = DAPI. Scale bars: A,B = 160 μm, D,E = 160 μm, F,G = 40 μm.