Figure 5: Gonadal testosterone does not influence sensitivity to low-dose ketamine in male rats. | Scientific Reports

Figure 5: Gonadal testosterone does not influence sensitivity to low-dose ketamine in male rats.

From: Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner

Figure 5

(a) Gonadectomized (GDX) male rats displayed a significantly lower sucrose preference when compared to SHAM & testosterone-supplemented male rats (**P < 0.01). Ketamine (KET; 2.5 mg/kg, i.p.) was without effect in male rats, regardless of hormonal status (Main Effects: Treatment/Day, ***P < 0.001; Hormone: **P < 0.01). Data are expressed as mean ± SEM (n = 30). (bd) Saline (SAL) baseline preference levels of all males were not associated with magnitude of response to KET (P > 0.05). (e) Gonadal testosterone depletion resulted in significantly less body weight gain throughout the experiment relative to SHAM-operated males (*P < 0.05). Chronic testosterone supplementation at the time of gonadectomy was sufficient to block this effect (P > 0.05). Data are expressed as mean ± SEM (n = 30).

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