Complexity improves overall performance of the cell cycle switch.
The performance of different networks was evaluated by calculating the standard deviation of the main molecular states ( or , depending on the network) over time. Standard deviations are calculated via numerical integration of the chemical master equation (CME) using the Visual GEC software and via numerical integration of the central limit approximation (CLA) in Matlab. We investigate switching in one direction or the other by providing different initial conditions that settle (more likely) in different steady states. (A) In the forward direction, principal molecular states were initialised at 2 copies and complementary molecular states were initialised at 1 copy, as shown in Fig. 2C and Fig. 5B. (B) In the reverse direction, principal molecular states were initialised at 1 copy and complementary molecular states were initialised at 2 copies.