CTX and CA4 toxins execute glioma growth inhibitory effects in brain microenvironment.
(A) Glioma-implanted brain tissue was treated with CA4 and CTX and tumor spreading was quantified. Treatment started after day 1 to secure initial tumor growth. Brain tissue was treated with CA4 and CTX at 10 μM. (B) Quantification of tumor volume in CA4 and CTX treated tumor-implanted brain tissue. Quantification of tumor volume is given. Both CA4 and CTX significantly reduced tumor volume compared to controls. Quantification is given from three independent experiments. Means are given as ± SD, n = 7 per group, *P < 0.05 (Student’s unpaired t-test). Scale bar represents 1 mm.