Percentages of splenic Th9 and Th17 cells significantly increased in mice with hepatic fibrosis.
(A) Characterization of splenic Th9 and Th17 cells by flow cytometry in CCl4 administrated mice at the 0th, 4th, 6th, 8th and 12th week. (B) Change of percentages of splenic Th9 cells in mice at different time points. (C) Change of percentages of splenic Th17 cells in mice at different time points. *p < 0.05 vs. controls sacrificed at the same time point; #p < 0.05 vs. other subgroups with fibrosis. Data are presented as mean ± SD. (D) Correlation between splenic Th9 and Th17 cells in mice with liver fibrosis at the 8th week.