Figure 1 | Scientific Reports

Figure 1

From: Sulphur Atoms from Methionines Interacting with Aromatic Residues Are Less Prone to Oxidation

Figure 1

Oxidation-sensitive proteins are enriched in methionines.

(A) Methionine frequency in the group of H2O2-sensitive proteins (1646 proteins, methionine usage: 0.0259 ± 0.0100 [mean ± standard deviation]). (B) Methionine frequency in the subset of highly H2O2-sensitive proteins (774 proteins, methionine usage: 0.0270 ± 0.0100 [mean ± standard deviation]). (C) Empirical distribution of mean methionine content for 10,000 random samples from the human proteome. For each sample, the mean methionine content was obtained by averaging across 1646 proteins randomly chosen from the human proteome. The position of the mean value computed for the set of H2O2-sensitive proteins is indicated with the symbol *. (D) Same as described in (C), but each sample was formed by 774 randomly selected proteins. The position of the mean methionine content value computed for the set of highly H2O2-sensitive proteins is again marked by *.

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