Figure 3 : Binding of AZ to ODC induces global conformational change.

From: Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1

Figure 3

(a) Overlay of ODC C-domain from our structure (green) with that of human ODC dimer structure (orange, PDB code: 1D7K) shows that that N-domain (purple) moves by about 10° towards AZ1, in the ODC-cAZ1 complex. (b) C-terminal helix (orange) of the ODC dimer structure is anchored mainly by hydrophobic interactions and a hydrogen bond with the N-domain (white). Binding of AZ1 causes the N-domain residues (purple) to be shifted away from the C-terminal helix.