Figure 1 : Crystal structure of ODC-cAZ1 complex.

From: Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1

Figure 1

(a) ODC-cAZ1 complex forms a heterodimer, which consists of one ODC monomer and one AZ1 molecule (pink). AZ1 is embedded into a concave surface formed between the N- (purple) and C-domains (green) of ODC. PLP is shown as sticks (green). (b) Stereo image of the electron density map (2Fo-Fc; σ = 1.0) for a region of cAZ1 (pink, residues 148–158). (c) Overlay of N-terminal domain of ODC from our structure (purple) with that of human ODC dimer structure (yellow, PDB code: 1D7K) reveals no change in protein fold. PLP from ODC dimer structure is shown as sticks (magenta). (d) Overlay C-terminal domain of ODC from our structure (purple) with that of the human ODC dimer structure (yellow, PDB code: 1D7K) reveals almost no change in protein fold.