Comparison between thulium laser resection of prostate and transurethral plasmakinetic resection of prostate or transurethral resection of prostate

Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-aged and elderly men. In the present study, we aimed to compare the efficacy and safety of thulium laser resection of the prostate (TMLRP) with either transurethral plasmakinetic resection of the prostate (TUPKP) or transurethral resection of the prostate (TURP). A literature search was performed, eventually, 14 studies involving 1587 patients were included. Forest plots were produced by using Revman 5.2.0 software. Our meta-analysis showed that operation time, decrease in hemoglobin level, length of hospital stay, catheterization time, and development of urethral stricture significantly differed, whereas the transitory urge incontinence rate, urinary tract infection rate, and recatheterization rate did not significantly differ between TMLRP and either TURP or TUPKP. The blood transfusion rate was significantly different between TMLRP and TURP, but not between TMLRP and TUPKP. In addition, the retrograde ejaculation rate between TMLRP and TURP did not significantly differ. At 1, 3, 6, and 12 months of postoperative follow-up, the maximum flow rate, post-void residual, quality of life, and International Prostate Symptom Score did not significantly differ among the procedures. Thus, the findings of this study indicate that TMLRP may be a safe and feasible alternative.

PVR. Pooled data revealed that there were no significant differences between TMLRP and either TURP or TMLRP in terms of the PVR during the 1-, 3-, 6-, and 12-month postoperative follow-up (all p ≥ 0.05, Table 2).
Local complication rate. There was no significant difference between TMLRP and either TURP or TUPKP in the transitory urge incontinence rate  Fig. 6b, respectively).

Discussion
To our knowledge, the present study is the first meta-analysis to compare the safety and efficacy of the TMLRP technique with either the TURP or TUPKP technique in patients with BPH. TURP is reportedly associated with a significant complication rate of 11.1% 2 . Moreover, TUPKP is a bipolar electrosurgical procedure that can notably reduce complications such as blood loss and other disadvantages associated with TURP [25][26][27] . Various laser treatment options have been developed in recent years. Recently, the thulium laser-a new type of surgical laser-is being increasingly applied in the urology field and overcomes many of the limitations of TURP and TUPKP, with encouraging efficacy and safety 28,29 . These new laser-based treatments can markedly improve the safety of patients and yield excellent results 28 .
Our meta-analysis showed that the TMLRP group exhibited ideal results as compared to the TUPKP and TURP group in terms of Qmax, PVR, IPSS, and QoL. And the QoL was slightly higher in the TMLRP group as compared to the TURP and TUPKP groups at the 1-month follow-up, and a significant  difference was noted. All the micturition parameters of the three groups were similar at the subsequent follow-ups. Our study demonstrated that TMLRP was as effective as TURP and TUPKP in improving patient symptoms and urodynamic measurements postoperatively. Compared with TURP or TUPKP, our meta-analysis demonstrated that TMLRP had a longer operation time. Xia et al. 22 showed that TMLRP had a shorter operation time than TURP, although the difference was not significant. There may be three potential explanations for the longer operation time in the TMLRP group. First, the surgeons may have been more experienced in performing TURP or TUPKP techniques. In contrast, TMLRP is a newer technique, and although the procedure is easy to learn, surgeons need time to overcome the learning curve. Second, the resection volume of prostate tissue may be greater in the TMLRP group than in either the TURP or TUPKP group. Third, TMLRP combines the resection and simultaneous vaporization processes, thus resulting in a longer operation time for tissue-cutting 15,19,22 . Even though TMLRP had a longer operation time, our meta-analysis indicated that this technique was associated with a lower decrease in serum hemoglobin level, a shorter catheterization time and length of hospital stay, and a lower risk of local complications compared with the other two methods. In addition, our meta-analysis also demonstrated that TMLRP was associated with a lower blood transfusion rate than TURP.
The decrease in serum hemoglobin levels and blood transfusion rate was lower in the TMLRP group, as compared with the TURP or TUPKP group. In fact, among the TMLRP patients included in our meta-analysis, only one patient needed blood transfusion in the study by Kim et al. 11 . This finding may be explained by the excellent coagulation offered by these techniques, considering that the thulium laser wavelength is superior for controlling bleeding during the operation. The central wavelength of the thulium laser used in TMLRP can be adjusted between 1.75 and 2.22 μ m, which enables the matching of this wavelength with the water absorption peak (1.92 μ m) in tissue. The high density of absorbed energy at the tissue surface leads to instant vaporization and limits the penetration depth from 0.5 to 2 mm, thus indicating that the thulium laser may yield a sufficient hemostasis effect with minimal risk of thermal injury to surrounding tissue 29 . Due to sufficient hemostatic capacity, the thulium laser also provides a surprisingly visual field, along with low blood loss during surgery 30 . As an added benefit, the patients' urine becomes clear more quickly after surgery, thus decreasing both the catheterization time and length of hospital stay. Of course, this may also be attributed to the decreased thermal damage and reduced scar formation as well as lower frequency of urethral stricture after the laser incision 31 .
We also performed a meta-analysis of the local complication rates between TMLRP and either TURP or TUPKP, including complications such as transitory urge incontinence, UTI, and recatheterization. The present meta-analysis indicated that there was a slightly better improvement of the abovementioned adverse events in the TMLRP group as compared with either the TURP or TUPKP group. In addition, the retrograde ejaculation rate was evaluated between the TMLRP and TURP groups, but no significant difference was noted. Although the findings of the present study support the results of previous clinical trials [11][12][13][14][15][16][17][18][19][20][21][22][23][24]32 , they still require verification in a large study.
Our meta-analysis does have certain limitations. Some of the results (such as Qmax, PVR, QoL, IPSS, operation time, decrease in hemoglobin level, length of hospital stay, and catheterization time) were associated with certain heterogeneities. These heterogeneities may be a result of several factors such as differences in prostate volume, operator skill, and follow-up duration; insufficient or unclear allocation concealment and blinding. In addition, a major limitation of this study may be our consideration of both thulium laser enucleation and thulium laser vaporesection as TMLRP. Another limitation was the limited number of well-constructed prospective trials; only four CCTs were included in our analysis. Furthermore, the difference in the resected weight of the prostate may have an influence on the results, particularly the operation time values. Nevertheless, we applied a sensitivity analysis to explore the reliability of our meta-analysis results. The results of this analysis did not indicate any substantial change in our initial conclusions. Thus, it also strengthened our level of confidence in the meta-analysis findings and credibility of the pooled results.
In conclusion, although our analysis found that TMLRP was associated with a longer operation time than either TURP or TUPKP, patients undergoing TMLRP might yield other benefits such as lower decreases in serum hemoglobin levels, shorter length of hospital stay and catheterization time, and a lower rate of urethral stricture. In addition, our analysis found that TMLRP was also associated with a lower blood transfusion rate than TURP. Moreover, TMLRP demonstrated similar efficacy in terms of Qmax, IPSS, PVR, and QoL at 1, 3, 6, and 12 months of postoperative follow-up and similar safety in terms of local complications such as transitory urge incontinence, UTI, and recatheterization as compared with either TURP or TUPKP. Our data suggest that TMLRP is a promising, minimally invasive technique that is a safe and feasible alternative to TURP or TUPKP for patients with BPH. Of course, more rigorously designed, larger, high-quality RCTs are required for further verification of these findings. Inclusion and exclusion criteria. Relevant studies were included in this systematic review and meta-analysis if they met the following criteria: (1) compared TMLRP with either TUPKP or TURP, (2) clearly documented the indications for resection of the prostate, (3) provided data for at least one of the predefined outcome measurements. In contrast, studies were excluded if (1) the inclusion criteria were not met or (2) data were not provided or were impossible to calculate for TMLRP or TUPKP or TURP. All study titles and abstracts were independently screened by the same reviewers, and the complete texts were reviewed when deemed necessary. Discrepancies were resolved through consultation with another author.
Data extraction. The following variables from each study were recorded independently by two reviewers: first author name, publication year, research design type, intervention method, total number of patients enrolled, patient age, prostate volume, PSA level, Qmax, PVR, QoL, IPSS, and follow-up period duration. In addition, the following outcome measures were extracted: operative time, hemoglobin level decrease, length of hospital stay, catheterization time, blood transfusion rate, and rates of local complications, with the latter including transitory urge incontinence, UTI, recatheterization, retrograde ejaculation, and urethral stricture. Discrepancies were resolved by reaching a consensus between all authors contributing to this review. Quality assessment. The quality of the RCTs included in this systematic review was assessed independently by two reviewers by using the Jadad scale score 33 , which ranges from 0 to 5 points-the higher the score, the better the quality indication. A study with a Jadad score of 3 points or more was considered as a high quality study. The Jadad score evaluates studies based upon their randomization, blinding, and descriptions of participant withdrawals and dropouts. CCTs that were included in the review were assessed through a modification of the Newcastle-Ottawa Scale 34 . The review scores ranged from 0 to 9 points for each trial; scores between 0 and 4 implied low-quality, while those between 5 and 9 implied high-quality. Discrepancies were resolved by consultation with another author. Statistical analysis. This meta-analysis was conducted using the Review Manager 5.2.0 (Cochrane Collaboration, Oxford, UK). For continuous data, the data were expressed as the MD with a 95% CI. For dichotomous data, the data were expressed as the OR with a 95% CI. In both cases, a p value of <0.05 was considered statistically significant. Heterogeneity was analyzed using a chi-square test with N-1 degrees of freedom, wherein an alpha value of 0.01 was used to imply statistical significance, in conjunction with the I 2 test. When I 2 was < 50%, heterogeneity was deemed acceptable. In addition, a fixed-effects model was used for the meta-analysis; otherwise, a random-effect model was used.