Table 1: Table showing a list of 6 genes/CpG clusters which show Pb dependent change in DNA methylation status in CNBS exposed in-utero to high BLL (high BLL MNBS).

From: Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

GeneCpG islandPromoterEffect sizeStandard
error
P-valueFDRCpG sites/cluster
NDRG4chr16:58535040-58535596No (TSS)0.140.040.0007290.0285
NINJ2non CpGYes−0.240.060.0001680.0132
TRPV2non-CpGYes−0.110.021.29E-060.00052
DOK3non-CpGNo (TSS)−0.080.024.46E-070.000304
APOA5chr11:116661034-116661410No0.050.010.000770.0293
Enhancerchr2:8596907-8597573NA0.0903290.0286560.001620.04272
  1. CpG sites, chromosome (chr) and location of CpG island. Promoter, CpG sites located at the promoter (Yes) or transcription start site (TSS). Effect size, the average change in DNA methylation at the CpG island (e.g., 0.05 is a 5% increase in average DNA methylation). CpG sites/cluster, the number of CpG sites with significant changes in the cluster.