Figure 6 | Scientific Reports

Figure 6

From: Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits

Figure 6

Alignments of α8 epitope sequences for mammals.

The human KIRVNGTKEPIEFKSNQWF sequence including R82, K87 and Ser94 key residues and 84NGT86 N-glycosylation sequence and NYSFKDILR including K205/D206 key residues are aligned with 20 mammalian and three avian sequences including chicken. Non-conserved residues are shown in grey. Human key residues and the corresponding residues in other species are shown in boxes. N-glycosylation sequences are underlined. Mnemonic organic identification codes of the UniProtKB data base are shown to the left of the sequences: CANFA represents Canis familiaris (Dog), UniProtKB ID of the source protein is F1PVR1; AILME, Ailuropoda melanoleuca (Giant panda), G1L8J0; MUSPF, Mustela putorius four (European domestic ferret), M3YJ77; PONAB, Pongo abelii (Sumatran orangutan), H2N9U6; PANTR, Pan troglodytes (Chimpanzee), H2Q1N7; NOMLE, Nomascus leucogenys (Northern white-cheeked gibbon), G1RP84; CALJA, Callithrix jacchus (White-tufted-ear marmoset), F7ALM4; MACMU, Macaca mulatta (Rhesus macaque), F7HGW0; OTOGA, Otolemur garnettii (Small-eared galago), H0WXM0; FELCA, Felis catus (Cat), M3VY58; SPETR, Spermophilus tridecemlineatus (Thirteen-lined ground squirrel), I3MA05; MONDO, Monodelphis domestica (Grey short-tailed opossum), F6TCV7; SARHA, Sarcophilus harrisii (Tasmanian devil), G3WIG1; LOXAF, Loxodonta africana (African elephant), G3TW88; FICAL, Ficedula albicollis (Collared flycatcher), U3JYV4; and TAEGU, Taeniopygia guttata (Zebra finch), H0YSX9. The human, mouse and chicken sequences were reviewed by UniProtKB.

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