Table 1 Phenotypic homogeneity of disease categories. We compute ROCAUC values for top-level categories in DO. Diseases are ranked based on phenotypic similarity, true positive matches are diseases in the same top-level DO category and negative matches are diseases in different DO categories.

From: Analysis of the human diseasome using phenotype similarity between common, genetic and infectious diseases

Disease category ROCAUC
bacterial infectious disease (DOID:104) 0.743 ± 0.057
cardiovascular system disease (DOID:1287) 0.720 ± 0.045
disease by infectious agent (DOID:0050117) 0.738 ± 0.035
disease of cellular proliferation (DOID:14566) 0.672 ± 0.021
disease of mental health (DOID:150) 0.783 ± 0.049
disease of metabolism (DOID:0014667) 0.733 ± 0.053
endocrine system disease (DOID:28) 0.711 ± 0.076
fungal infectious disease (DOID:1564) 0.864 ± 0.072
gastrointestinal system disease (DOID:77) 0.718 ± 0.045
genetic disease (DOID:630) 0.656 ± 0.0707
immune system disease (DOID:2914) 0.730 ± 0.046
integumentary system disease (DOID:16) 0.743 ± 0.051
musculoskeletal system disease (DOID:17) 0.704 ± 0.048
nervous system disease (DOID:863) 0.712 ± 0.026
parasitic infectious disease (DOID:1398) 0.729 ± 0.070
physical disorder (DOID:0080015) 0.593 ± 0.113
reproductive system disease (DOID:15) 0.868 ± 0.048
respiratory system disease (DOID:1579) 0.868 ± 0.047
syndrome (DOID:225) 0.613 ± 0.138
thoracic disease (DOID:0060118) 0.659 ± 0.212
urinary system disease (DOID:18) 0.870 ± 0.050
viral infectious disease (DOID:934) 0.745 ± 0.074