Comprehensive somatic mutational landscape of BRAF as PAN-cancer driver.
Distribution of somatic mutations are shown, for five TCGA tissues with significant BRAF mutations: skin cutaneous melanoma (SKCM), thyroid adenocarcinoma (THCA), colon adenocarcinoma (COAD), lung adenocarcinoma (LUAD), glioblastoma multiforme (GBM). Diamonds indicate mutation type of non-synonymous mutations in red, splice-site mutations in orange, indels in brown, stop in black and silent protein-coding mutations in white. Numbers refer to codons. Each filled circle represents an individual mutated tumour sample. The RAS binding domain (RBD) of BRAF is colored in magenta. The protein kinase (PK) domain of BRAF is colored in blue with the ATP binding site highlighted in yellow and the activator loop around residue 600 in purple. Domains are colored accordingly. Residues affected by coding somatic mutations of BRAF, NCBI Gene ID 673, are depicted in sticks onto ribbon structure of 3ny5.pdb and 4e26.pdb.