Table 1 Genotype and minor allele frequencies of 9 SNPs in 6 genes in morning, intermediate and evening types

From: Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder

     M (N = 245) I (N = 594) E (N = 86) M I E  
Gene SNP Allele (A/a) Variation (amino acid) AA Aa aa AA Aa aa AA Aa aa MAF P (χ2)
CLOCK rs1801260 T/C   0.714 0.269 0.016 0.714 0.263 0.024 0.64 0.302 0.058 0.151 0.155 0.209 0.162
NPAS2 rs2305160 G/A A/T 0.629 0.322 0.049 0.677 0.288 0.035 0.628 0.291 0.081 0.21 0.179 0.227 0.163
PER1 rs2585405 C/G P/A 0.339 0.502 0.159 0.347 0.461 0.192 0.349 0.512 0.14 0.41 0.423 0.395 0.75
PER2 rs2304672 C/G   0.873 0.127 0 0.904 0.094 0.002 0.872 0.128 0 0.063 0.049 0.064 0.411
  rs934945 G/A G/E 0.478 0.396 0.127 0.476 0.441 0.082 0.465 0.43 0.105 0.324 0.303 0.32 0.662
PER3 rs228697 C/G P/A 0.898 0.102 0 0.833 0.163 0.003 0.791 0.186 0.023 0.051 0.085 0.116 0.01*
  rs2640909 T/C M/T 0.812 0.184 0.004 0.771 0.214 0.015 0.767 0.198 0.035 0.096 0.122 0.134 0.238
TIM rs774047 A/G Q/R 0.363 0.449 0.188 0.347 0.463 0.19 0.372 0.43 0.198 0.412 0.422 0.413 0.927
  rs2291739 C/T P/L 0.347 0.445 0.208 0.301 0.49 0.209 0.326 0.442 0.233 0.431 0.454 0.453 0.679
  1. A, major allele; a, minor allele; M, morning type; I, intermediate type; E, evening type; N, number; P, P value for the difference in MAF among M, I and E;
  2. *, P < 0.05.