Figure 8 : Continuum model for cortical and subcortical growth.

From: A mechanical model predicts morphological abnormalities in the developing human brain

Figure 8

The cortex, the gray matter, grows morphogenetically at a constant rate Gc. Cortical growth induces subcortical deformation, which triggers subcortical growth. The subcortex, the white matter, grows at a stretch-dependent rate as Gs(JeJ0), where Gs mimics the axon elongation rate and JeJ0 activates growth only, if the elastic volume stretch Je exceeds its baseline value J0. The subcortical volume growth mimics the three-dimensional effect of chronic axon elongation , which is activated when axons are stretched beyond their physiological limit.