Figure 5 : Pathology and simulation of lissencephaly.

From: A mechanical model predicts morphological abnormalities in the developing human brain

Figure 5

(a) Magnetic resonance images of a lissencephalic brain display an increase in cortical thickness, a decrease in depth and number of cortical gyri and sulci, and a decrease in subcortical volume. (b), (c) Simulated morphologies for a moderately and severely increased cortical thickness display the formation of a single shallow gyrus and the complete suppression of gyrification.