Table 2 Association of TLR SNPs with SLE in the study population (n = 795)

From: Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population

     Frequency Allelic Association Genotypic Association: Additive Genotypic Association: Dominant Genotypic Association: Recessive
SNP Position Sample Risk Allele SLE (N = 795) Normal (N = 1162) P OR (95%CI) P OR (95%CI) P OR (95%CI) P OR (95%CI)
TLR3              
rs3775291 Chr4 All G 1036 (65.16%) 1496 (64.37%) 0.358 1.08 (0.92–1.26) 0.359 1.08 (0.92–1.25) 0.357 0.86 (0.63–1.18) 0.060 1.23 (0.99–1.52)
  187004074 Male A 48 (35.29%) 352 (34.31%) 0.999 1 (0.68–1.48) 0.999 1 (0.67–1.49) 0.703 0.9 (0.53–1.54) 0.558 1.27 (0.58–2.77)
   Female G 948 (65.2%) 822 (63.33%) 0.305 1.09 (0.92–1.29) 0.309 1.09 (0.92–1.29) 0.453 0.88 (0.62–1.23) 0.056 1.25 (1–1.58)
rs3775296 Chr4 All T 401 (25.22%) 585 (25.17%) 0.860 0.98 (0.83–1.17) 0.859 0.98 (0.83–1.17) 0.469 0.92 (0.75–1.14) 0.295 1.26 (0.82–1.95)
  186997767 Male G 108 (79.41%) 756 (73.68%) 0.254 1.31 (0.83–2.06) 0.268 1.29 (0.83–2.01) 0.901 0.94 (0.34–2.59) 0.143 1.52 (0.87–2.64)
   Female T 373 (25.65%) 315 (24.27%) 0.727 1.03 (0.86–1.24) 0.724 1.03 (0.86–1.25) 0.925 0.99 (0.79–1.24) 0.270 1.32 (0.81–2.15)
TLR7              
rs3853839 ChrX All G 1259 (82.77%) 1405 (77.67%) 0.001 1.35 (1.13–1.62)       
  12907658 Male G 57 (85.07%) 389 (76.13%) 0.126 1.76 (0.86–3.64)       
   Female G 1202 (82.67%) 1016 (78.27%) 0.002 1.38 (1.12–1.69) 0.002 1.38 (1.12–1.69) 0.133 1.58 (0.87–2.87) 0.003 1.44 (1.14–1.83)
rs5935436 ChrX All T 64 (4.2%) 65 (3.59%) 0.308 1.22 (0.83–1.77)       
  12883891 Male C 66 (97.06%) 494 (96.3%) 0.927 0.93 (0.2–4.3)       
   Female T 62 (4.26%) 46 (3.54%) 0.219 1.3 (0.86–1.97) 0.219 1.30 (0.86–1.98) 0.269 1.27 (0.83–1.95) 0.980 N/A
rs179010 ChrX All T 565 (37.12%) 612 (33.81%) 0.097 1.14 (0.98–1.32)       
  12902885 Male T 26 (38.24%) 165 (32.23%) 0.295 1.34 (0.78–2.32)       
   Female T 539 (37.07%) 447 (34.44%) 0.257 1.1 (0.93–1.3) 0.265 1.1 (0.93–1.3) 0.365 1.11 (0.88–1.4) 0.349 1.17 (0.84–1.64)
TLR8              
rs3764880 ChrX All G 1286 (84.55%) 1444 (79.73%) 0.033 1.23 (1.02–1.5)       
  12924826 Male G 58 (86.57%) 377 (73.49%) 0.054 2.09 (0.99–4.41)       
   Female G 1228 (84.46%) 1067 (82.2%) 0.296 1.12 (0.9–1.39) 0.296 1.12 (0.9–1.39) 0.781 1.1 (0.55–2.2) 0.272 1.15 (0.9–1.47)
  1. For all samples, the test p-value was adjusted by age and sex; for the males and females, the test p-value was adjusted by age respectively.