Figure 6 : Schematic representation of early events following amputation.

From: Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed

Figure 6

Amputation triggers a sustained ROS production that induces apoptosis and JNK signaling. Both signaling pathways are important for epidermal cell proliferation at 24 hpa and are necessary for blastema formation. ROS through Apoptosis signaling stimulates pluripotency marker expression.