Figure 5 : Deduced essential pathways based on S. sanguinis essential genes.

From: Genome-wide essential gene identification in Streptococcus sanguinis

Figure 5

Colors indicate the three functions associated with essential pathways, as in Figure 2. I, glycolysis and pyruvate oxidation; II, peptidoglycan biosynthesis; III, terpenoid backbone biosynthesis; IV, glycerolipid metabolism (LTA biosynthesis); V, WTA biosynthesis; VI, lipopolysaccharide biosynthesis; VII, MAP biosynthesis; VIII, phosphoglycerolipid metabolism; IX, fatty acid biosynthesis; X, electron transport chain; XI, pentose phosphate pathway; XII, nucleotide biosynthesis; XIII, genetic information processing including DNA replication, transcription, protein biosynthesis, GTP-binding proteins and cell division. Black arrow, all bacteria; black dashed arrow or oval, alternative pathways; blue arrow, gram-positive bacteria only; green arrow, gram-negative bacteria only; violet arrow, mycobacteria only; bold arrow, synthesis of cell envelope. CA, chorismate; Cyt, cytochrome; DAG, 1,2-diacylglycerol; DG-DAG, diglucosyl-diacylglycerol; G3P,D-glyceraldehyde 3-phosphate; GPGGL, glycerophosphoglycoglycerolipid; L-G3P, glycerol-3-phosphate; LPS, lipopolysaccharide; Malonyl-ACP(CoA), malonyl-ACP or malonyl-CoA; M-DAP, meso-2,6-diaminopimelate; MEV, mevalonate; MG-DAG, monoglucosyl-diacylglycerol; PA, phosphatidate; PG, phosphatidylglycerophosphate; R-5-P, D-Rribulose 5-phosphate; PPP, pentose phosphate pathway; PtdGro, phosphatidylglycerol; UDP-MAG, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate; UPP, undecaprenyl diphosphate.