Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Endodontic surgery

Key Points

  • Explains the role of surgery in managing endodontic failures.

  • Reviews correct case selection and impact on surgical outcome.

  • Provides an update on techniques and materials in endodontic surgery.

Abstract

A better understanding of endodontic disease and the causes of treatment failure has refined the role of surgery in endodontics. The advent of newer materials, advances in surgical armamentarium and techniques have also led to an improved endodontic surgical outcome. The aim of this article is to provide a contemporary and up-to-date overview of endodontic surgery. It will focus primarily on the procedures most commonly performed in endodontic surgery.

Introduction

The biological aim of endodontic treatment is to prevent or resolve apical periodontitis by controlled asepsis or through decontamination of the root canal system so as to create an environment in which periradicular healing can occur. However, if non-surgical root canal treatment is not possible or disease or symptoms persists following root canal treatment, endodontic surgery may be necessary in order to salvage a tooth.

There have been significant advances in endodontic surgery in the last two decades; gone are the antiquated, mechanistic procedures to be replaced by biological approaches, newer materials, aided by enhanced illumination and magnification, micro-surgical armamentarium and techniques. As a result, 'endodontic surgery' has evolved and is now often referred to as 'endodontic microsurgery'. These advances have helped improve the outcome of endodontic surgery, which was previously considered to be a rather unpredictable procedure, carried out in desperation and as a last resort. Indeed, contemporary micro-surgical techniques and newer root-end filling materials have reported a favourable healing outcome of 88–96%.1,2,3,4

The aim of this article is to provide a contemporary and up-to-date overview of endodontic surgery. It is beyond the scope of this article to provide exhaustive coverage, including comprehensive technical details of every endodontic surgical procedure; therefore, it will focus primarily on the procedures most commonly performed - periradicular curettage, root-end resection, root-end cavity preparation and root-end filling; previously also referred to as periapical curettage, apicectomy, retrograde cavity preparation and retrograde filling respectively.

Indications for endodontic surgery

There used to be a plethora of indications for endodontic surgery; much of which were related to difficulties in (re-)gaining access to the root canal system for non-surgical retreatment. However, modern non-surgical retreatment techniques allow improved ability to gain coronal and radicular access; coupled with a better understanding of the causes of treatment failure, the preference is to carry out non-surgical root canal retreatment before considering endodontic surgery.5,6 Unless the root canal system is cleaned, shaped and filled, viable microorganisms may persist even after endodontic surgery constituting a potential risk factor for recurrence of periradicular pathosis. The idea that it is possible to contain microbes within the root canal system by carrying out endodontic surgery alone is not only untrue but dated and misguided (Fig. 1). As a result, the indications for endodontic surgery7,8 are reduced to the following:

  • Persistent disease (with or without symptoms) in a previously root-filled tooth where non-surgical root canal retreatment cannot be undertaken, is not feasible or has failed; for example, the presence of a post of significant size and length whose removal carries a high risk of root fracture

  • Correction of iatrogenic errors not amenable to a non-surgical approach; for example, the removal or retrieval of extruded root filling material or a fractured instrument

  • Biopsy or surgical investigation required; for example, a biopsy may be required for histopathological analysis of a suspicious-looking lesion or direct visualisation necessary to explore a suspected root fracture

  • As a combined approach, in conjunction with non-surgical retreatment to resolve multiple technical problems; for example, a large periradicular lesion, a suspected radicular cyst, impossible to maintain a dry canal and a wide-opened apex in an immature permanent anterior tooth. A combined approach may also be part of anatomical redesigning (root amputation, tooth resection, bicuspidisation) with periodontal-endodontic cases

  • Where patient factors dictate that it may be more expedient to consider a surgical rather than a non-surgical root canal retreatment approach.

Figure 1: Mandibular first and second molars, previously root filled.
figure1

(a) Sub-optimal root fillings and poorly-fitting coronal restorations. Endodontic surgery carried out under general anaesthetic; root-ends incompletely resected and amalgam root-end fillings that are also incorrectly placed. Is it a surprise a second round of endodontic intervention also failed? (b) Non-surgical root canal retreatment should have been carried out instead; a favourable outcome in the end despite all the iatrogenic damage to the roots of both teeth

Contra-indications for surgical endodontics

There are not many contraindications for endodontic surgery; they may be divided into general and local factors.

General

  • Patient factors including psychological considerations and systemic disease for example, bleeding dyscrasias

  • Clinician factors including the training, skill and experience of the operator, availability of equipment and facilities.

Local

  • Dental factors including restorability of the tooth, root length, periodontal support and the patient's oral hygiene status

  • Anatomical factors including the proximity of neurovascular structures. For example, the inferior alveolar and mental nerves may be at risk with surgery of mandibular molars and premolars; similarly, the palatal neurovascular bundle with a palatal flap

  • Surgical access factors. For example, the ability of a patient to open their mouth wide, which will affect the operator's ability to easily see and access the surgical site. In the posterior region of the mandible the extended width of the external oblique ridge, when combined with lingually-placed root apices of molar teeth, may complicate visibility and access. Another example is the presence of a large bony exostosis, which may make incision and reflection of a flap considerably more difficult.

Pre-operative assessment

The pre-operative assessment includes a full medical and dental history, extra-oral and intra-oral examinations, and special investigations including radiographs. Radiographs should be taken using the paralleling technique with a beam-aiming device to provide the best views and good diagnostic yields. The full root/s and approximately two to three mm of the periradicular region should be included.9

Newer three-dimensional (3-D) imaging techniques such as cone beam computed tomography (CBCT) have been recommended for pre-operative planning of surgical cases to determine the exact location of root apices and to evaluate the proximity of adjacent anatomical structures.10,11 The need for a CBCT scan should be decided on a case-by-case basis. To keep the patient's radiation exposure as low as reasonably possible, a risk versus benefit analysis should be carried out beforehand. If deemed necessary, the CBCT scan should be of limited volume and high resolution.

One of the aims of the pre-operative assessment is to anticipate and minimise procedural or healing complications. Potential risks, difficulties and complications should be discussed with the patient as part of the process of obtaining informed consent before surgery. Post-operative sequelae such as scarring, gingival recession, denudation of the interdental papilla may alter the anatomical contours and aesthetics of soft tissues and existing coronal restorations. Therefore, it is important to be aware that, among other considerations, different gingival biotypes will dictate the outcome of soft tissue healing. Patients with a thin gingival biotype are prone to suffer from gingival recession post-surgery while those with a thick gingival biotype may end up with pocket formation.12 In addition, marginal periodontitis and loss of cortical bone from the buccal or lingual aspect that denudes the root surface have a significant negative affect on surgical outcome.13 The proximity of the maxillary sinus does not automatically preclude a particular tooth from endodontic surgery but it is generally considered advisable to try and avoid perforating the antrum or displace infected debris or a resected root tip into the maxillary sinus.14,15

Surgical equipment

It is now routine for endodontic surgery to be carried out using an operating microscope16 (Fig. 2). Therefore, specially-designed microsurgical instruments (Fig. 3) and techniques have been developed. Individual operators will have their own personal preferences when it comes to choice of instruments and equipment. An example of a surgical kit and a selection of suitable instruments are listed in Table 1.

Figure 2
figure2

Dental operating microscope, an invaluable tool in endodontic surgery

Figure 3
figure3

Microsurgical instruments: (left to right) plugger, material carrier and periosteal elevator

Table 1 Example of a surgical kit

Anaesthesia

In order to carry out endodontic surgery, profound anaesthesia and good haemostasis are essential. Lignocaine (lidocaine), combined with a vasoconstrictor, most commonly 1:80,000 adrenaline (epinephrine) in the local anaesthetic solution should fulfil these objectives.17 Felypressin, a non-catecholamine vasoconstrictor is less effective than adrenaline in achieving adequate haemostasis and should be avoided.

Depending on the surgical site, nerve block, infiltration or a combination of both local anaesthetic techniques may be necessary. Local anaesthetic in volumes of 0.5 ml is also normally deposited slowly at a rate of one to two ml per minute into numerous infiltration sites around the relevant tooth. The local anaesthetic solution should be delivered into the loose connective tissue of the alveolar mucosa near to the root apices. Placement too deep and into supraperiosteal tissues or frenal attachments may result in increased bleeding due to the predominance of β-2 receptors in skeletal muscle. The anaesthetic solution will be dispersed more rapidly and the duration of anaesthesia will, therefore, be reduced. Sometimes, an infra-orbital infiltration may be required for surgery in the maxillary canine or premolar region. Occasionally, in addition to local anaesthesia, conscious sedation or general anaesthesia may be necessary if the surgical procedure is complicated, significant discomfort or pain is anticipated or if the patient is anxious.

Pre-emptive analgesia

Pre-emptive analgesia, in simple terms, is the concept of stopping pain before it starts. It involves the administration of a pain management regime, commonly pharmacological, before anticipated noxious stimuli, thereby preventing or reducing central sensitisation of the nervous system to pain. Pre-emptive analgesia is a practice particularly suitable for any intervention in which the timing of the noxious stimuli is known; hence it is beneficial in endodontic surgery. A therapeutic dose of an analgesic drug is taken before pain developing rather than being required in response to it. This strategy has been shown to be effective in reducing pain during the post-operative period and results in fewer analgesics being required. Paracetamol (acetoaminophen) or non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen have been advocated for pre-emptive analgesia.18,19,20 Similarly, the administration of a nerve block injection of a long-acting anaesthetic drug such as bupivacaine, which lasts for up to eight to ten hours, may be of value in reducing post-operative pain.21

Pre-operative disinfection

A pre-operative chlorhexidine gluconate (0.2%) mouthrinse for one minute has been recommended as this reduces the intra-oral microbial load intra and improves post-operative healing by preventing the risk of infection.22,23

Flap design

There are many different flap designs that have been used in endodontics.8,24 The flap design chosen will usually and mainly be dependent on the surgical access required; however, it will also affect the post-surgical probing depth, gingival margin level and clinical attachment.25 Regardless of the design chosen, it should always follow the basic principles of ensuring that there is an adequate blood supply, and these days preservation or avoidance of the interdental papilla is preferred.

Semi-lunar flap

The semi-lunar flap design (Fig. 4) is inadequate in terms of providing good surgical access and is also associated with many post-operative complications including pain, swelling and scarring (Fig. 5). Therefore, the semi-lunar flap is contra-indicated for use in periradicular surgery.7,8,24

Figure 4
figure4

Semi-lunar flap design, no longer recommended

Figure 5
figure5

Post-surgical scarring from inappropriate flap design

Full thickness marginal flap

A primary incision is made in the gingival sulcus and follows the contours of the teeth. Relieving incisions crossing any bony defects should be avoided as this may hinder healing. The relieving incision is made with firm pressure starting at the gingival margin and extended through the attached gingiva in as vertical direction as possible to avoid severing supra-periosteal vessels and collagen fibres; this will reduce bleeding and improve healing. Extension deep into the sulcus is not normally required and can lead to increased bleeding into the operative site. One relieving incision (triangular flap) may provide sufficient visibility. However, two relieving incisions (rectangular flap) (Fig. 6) will provide greater surgical access. Healing is normally by primary intention and provided there is good oral hygiene, post-operative complications are rare.26

Figure 6
figure6

Rectangular, full thickness flap

A papilla-base incision has been advocated to preserve the interdental papilla and reduce post-surgical recession.27,28 The papilla-base flap (Fig. 7) consists of two different incisions at the base of the papilla; a perpendicular incision of the epithelium and a second sub-epithelial incision of the connective tissue resulting in a split thickness flap.

Figure 7
figure7

Papilla base flap, designed to avoid and preserve the interdental papilla

Submarginal (Luebke-Ochsenbein) flap

The submarginal flap (Fig. 8) is useful in the anterior maxilla especially if preservation of the gingival contours adjacent to crowned teeth is needed.29 The horizontal, scalloped incision is made approximately three mm from, and follows, the contours of the gingival margin, with one or two relieving incisions.30 Disadvantages of this flap design include the risk of flap shrinkage, delayed healing and scarring; it is also not suitable for use in the mandible.

Figure 8
figure8

Submarginal (Luebke-Ochsenbein) flap

Palatal flap

On occasions, in the maxilla, a palatal flap may be necessary. This full-thickness flap design with one or two relieving incisions will provide good access, for example, the palatal root of a maxillary molar. The anterior relieving incision is made at the mesio-palatal line angle of the first premolar and extended two-thirds of the distance to the apex of the palatal vault. If a distal relieving incision is required this should be made from the distal line angle of the last molar and is extended posteriorly. There is high risk of severing the palatine neurovascular bundle if a palatally-inclined relieving incision is used in the posterior region. Reflection of the flap can be difficult as the tissues are thicker and more firmly bound.

Flap reflection

The periosteal elevator should have a keen, undamaged blade to ensure atraumatic reflection of the flap. The instrument should not be inserted into the interdental papilla; the starting point for flap reflection should be at the relieving incision at the level of the alveolar mucosa.8 From this starting point (Fig. 9), it is advanced under the periosteum to undermine the tissues and moved gently in a lateral direction, maintaining contact with the cortical bone as the flap is reflected.29 Once the flap is fully reflected, a tissue retractor is used to protect and keep the flap in position. Newly designed retractors are better contoured; they have wider (15 mm) and thinner (0.5 mm) working ends compared to standard oral surgery retractors (Fig. 10). The retractor should rest on bone and not pinch the soft tissues to avoid damaging them. Occasionally it may be necessary to make a shallow locating groove in the cortical bone to prevent slippage of the retractor. Retractors with serrated ends, which are designed to improve anchorage, are also available.

Figure 9: Flap reflection.
figure9

Begin at the vertical relieving incision at the level of the alveolar mucosa (1); the flap is slowly undermined (2) and reflected (3, 4)

Figure 10
figure10

Micro-surgical (top) and standard surgical (bottom) retractors

Bone removal and root-end identification

Once the flap is reflected, the root-end has to be located and uncovered. If there is a periradicular lesion of significant size the overlying cortical bone may have already been perforated; in this case, the root-end is easy to locate (Fig. 11). A sharp excavator can be used to remove the thin cortical bone around the fenestration to enlarge the bony crypt.

Figure 11
figure11

Overlying cortical bone lost, root-end easily uncovered and identified

If there is no bony fenestration then the approximate location of the root-end may be estimated using pre-operative radiographs. The overlying bone will then have to be removed in order to uncover the root-end. Bone removal may be carried out using a round surgical bur in a slow-speed handpiece with sterile saline irrigation. However, a specially-designed, rear-vented high-speed handpiece (Impact Air 45, Palisades Dental LLC, Eaglewood, NJ, USA or Phatelus 45, NSK, Kanuma, Tochigi, Japan) may also be used. Tungsten carbide or steel burs, for example, Lindemann bur (Fig. 12), work best as they are less likely to be clogged with bone fragments and lead to heat generation. Bone is carefully removed using a light brush stroke action. The osseous window is then enlarged until there is sufficient space to see and access the root-end and the periradicular lesion.

Figure 12
figure12

Impact Air 45 high-speed handpiece with a Lindemann bur

Periradicular curettage

Periradicular curettage involves the removal of reactive soft tissue from around the root-end. Most periradicular lesions are the result of an inflammatory response to microbial infection within the root canal system or a foreign body reaction to any extruded material/irritant.

Periradicular curettage is normally carried out with a straight or angled surgical bone or periodontal curette (Fig. 13). The curette is first worked around the margins of the lesion with the convex surface innermost to reflect the lesion from the surrounding bone. The curette is then reversed to scoop out the soft tissue lesion.29 A biopsy if needed will entail either taking the whole or part of the curetted lesion for histopathological analysis. Any lesion that is removed should be immediately placed in formal saline and sent for histopathological examination.

Figure 13
figure13

Periradicular curettage of a large lesion

Sometimes even with profound anaesthesia the patient may be aware of discomfort when a lesion is being curetted. This may be due to increased neural budding within the centre of a lesion that has been stimulated by inflammatory mediators.31 Injecting local anaesthetic into the lesion over a few minutes will normally help resolve this problem.

In some instances, it may not be always possible to remove all the reactive tissues surrounding the root-end. Clinical evidence indicates no statistical significant difference in outcome between cases where complete and incomplete removal of reactive tissues has been achieved; therefore the priority should be given to preserving vital structures.32

Root-end resection

Unless accessible to root canal instruments, medicaments and irrigants, the complex apical architecture of infected teeth will harbour microbes. Resection of an apical two to three mm portion of the root end removes this nidus of infection;33 however, care must be taken not to remove an unnecessary amount of root as this will compromise the crown-to-root length ratio.

The root-end resection is normally carried out with a slow-speed or a specially-designed high-speed handpiece, same as for bone removal. It is no longer considered appropriate or necessary to cut the root down to the coronal edge of the bony crypt.29 In multi-rooted teeth it may be necessary to reduce the buccal roots slightly to provide adequate access to a lingually-placed root. If the bony crypt is small, or the soft tissues restrict reflection of the flap and access, then further reduction of the root may be necessary to make enough space for root-end cavity preparation. Alternatively, the bony crypt may be enlarged but unnecessary destruction and leaving less than one mm of crestal bone on the buccal aspect of the root may seriously affect treatment outcome. Once resected, an inspection is carried out of the cut root-end with the operating microscope, aided by micro-mirrors (Fig. 14), for smoothness, cracks and canal irregularities.16 Sometimes small knife-edges of root may be retained on the lateral borders, or if the root is angled, it may not have been adequately resected to expose the main root canal system. Methylene blue (1%) dye may be used to highlight the periodontal ligament, canal orifices, cracks and missed canals to ensure that resection is adequate and complete.34

Figure 14
figure14

Micro-surgical mirrors, significantly smaller than the conventional mouth mirror in the background, essential for examining the root-end after resection and cavity preparation

Historically, when the root-end is resected, bevelling was always carried in order to improve access for preparation of a cavity with a round bur for the root-end filling.35 However, current biological evidence and advances in preparation techniques, such as the use of surgical ultrasonic tips (see later) aided by an operating microscope, has meant that the root-end should be resected perpendicular to the long axis of the root and not bevelled.8,33 Apart from preserving more root length, a near horizontal resection avoids exposing more dentinal tubules on the cut root face, which can allow the leakage of microbial by-products and irritants from the root canal system even in the presence of a root-end filling.36,37

Root-end cavity preparation

Root-end cavity preparation should always be carried out with the aid of magnification, as it is easy to miss subtle root canal system features such as isthmuses and additional canals with the naked eye. Polished stainless steel and sapphire glass micro-mirrors are available to improve visualisation of the surface of the cut root-end (Fig. 15).

Figure 15
figure15

Micro-surgical mirror used to examine the cut root face

Root-end cavity preparation is carried out with specially-designed surgical ultrasonic tips (Fig. 16), which are available in different shapes, angles and configurations. Some are coated with diamond or other industrial coating (Fig. 17) and many have irrigant channels for improved cutting efficiency and debris removal. Normally, a root-end cavity is prepared to a depth of two to four mm.38,39 The root-end cavity preparation is angled along the long axis of the root and the lateral borders are dictated by the cross-sectional shape of the main root canal system following resection.

Figure 16
figure16

Ultrasound and specially-designed surgical tips are used to prepare the root-end cavity

Figure 17
figure17

Angled micro-surgical ultrasonic tip

Apart from being used to prepare the root-end cavity, ultrasonic tips are also used to debride and enlarge any canal anastomoses and isthmuses effectively; they help achieve a better shape and cleaner root-end cavity compared with using burs.34,39,40,41 After the root-end cavity is prepared it is cleaned with sterile saline and then gently dried with paper points, or preferably a Stropko irrigator (Fig. 18), a specially modified micro-surgical three-in-one syringe tip.

Figure 18
figure18

Stropko irrigator, useful for drying the root-end cavity

Haemostasis

Good haemostasis must be achieved before placement of the root-end filing.42,43 An aspirating micro-tip will help control small, localised bleeds. However, placement of a haemostatic agent within the bony crypt may be necessary for more effective control of bleeding; these include:

Gauzes and adrenaline

Pure surgical gauze that is fabricated from non-cotton fibres (therefore less likely to initiate post-operative inflammation) and soaked in 1:1,000 adrenaline or local anaesthetic solution containing 1:80,000 adrenaline may be packed firmly into the bony crypt. If 1:1,000 adrenaline is used it should not be left in the bony crypt for a prolonged period; normally 30 seconds should suffice.

Cellulose-based, collagen-based and absorbable gelatine products

Surgicel (Ethicon, Johnson & Johnson, Wokingham, Berks, UK), a cellulose-based material, encourages clot formation. However, it has been recommended that the material is removed following root-end filling as it is not absorbable and may initiate a foreign body inflammatory response.44,45

Hémocollagène (Septodont, Saint-Maur-des-Fossés, France) (Fig. 19) and Collacote (Colla-Tec Inc. Plainsborough, NJ, USA) are lyophilised collagen-based materials. Absorbable collagen-based agents can be left in the bony crypt and should not interfere with healing.26

Figure 19
figure19

Collagen-based haemostatic sponge

When used as a haemostatic agent, Spongostan (Ethicon), an absorbable gelatine sponge, has been reported to elicit no adverse tissue reaction but delayed healing was observed.46

Ferric sulphate

Ferric sulphate solution, for example, Astringedent or ViscoStat (Ultradent, South Jordan, UT, USA), Cut-Trol (Ichthys Enterprises, Mobile, AL, USA) or Stasis (Gingi-Pak, Camarillo, CA, USA) causes agglutination of blood proteins on contact; this in turn results in plugging of opened capillaries. However, the solution should be used sparingly as it has been associated with post-operative complications.46 Therefore, the bony crypt should be gently curetted and any remnant washed out following use.

Root-end filling

Every dental restorative material and cement ever formulated has, at one time or another, been suggested for root-end filling. The requirements of an ideal root-end filling material are well documented (Table 2) but, currently, there does not appear to be a material that fulfils all these requirements.47

Table 2 The requirements of an ideal root-end filling material

Traditionally amalgam, ubiquitous in dentistry, was the root-end filling material of choice. However, amalgam can no longer be considered an appropriate root-end filling material and should be permanently consigned to history. Amalgam is prone to corrosion and disintegration; excess amalgam and the release of metal particles into the surrounding tissue and gingiva can result in amalgam tattooing. The presence of mercury in amalgam may also be a concern to patients. In addition, the healing characteristics following root-end filing with amalgam are questionable.47 Newer root-end filling materials have better sealing ability and are more biocompatible. There is good evidence for the use of the following,47 commonly available, newer root-end filling materials:

Zinc oxide-eugenol (ZOE) cements

Reinforced zinc oxide eugenol cement, such as intermediate restorative material (IRM) and ethoxybenzoic acid (EBA) cement, has been advocated as a root-end filling material for many years.47 The biological properties of ZOE cements are dependent on their formulation. Unmodified ZOE cements that are not reinforced are weaker and have a longer setting time and hence they are not suited as root-end filling materials.

IRM and EBA cement are acceptable for root-end filling. A micro-apical carrier or fine carver for example, half Hollenback, may be used to place, and micro-pluggers used to pack, IRM or EBA cement into the root-end cavity. The filling is burnished and when set it may be finished with an ultra-fine fluted tungsten carbide bur to leave a smooth surface (Fig. 20). Reinforced ZOE cements, such as IRM, produce a better seal than amalgam and following its use as a root-end filling material, periradicular healing has generally been shown to be good.1,48

Figure 20
figure20

Buccal roots of a maxillary first molar sealed with IRM and polished

Mineral trioxide aggregate (MTA)

MTA is a fine powder with a similar basic chemical composition to Portland cement. Unsurprisingly, it has a sand-like consistency when hydrated not unlike building mortar. The material has a long setting time (two hours 45 minutes), which may be the reason for its superior sealing ability.47,49 Various other versions of accelerated setting MTA have now appeared on the market; for example, a Brazilian version, MTA-Angelus (Angelus Dental Solutions, Londrina, Parana, Brazil), is claimed by the manufacturer to have an initial setting time of ten minutes while MM-MTA (Micro-Mega, Besançon Cedex, France), with the addition of calcium carbonate, has a reduced setting time of 20 minutes.

MTA has consistently shown to be an excellent root-end filing material; it is hydrophilic and biocompatible.49 Given its consistency and long-setting time, MTA can be challenging to manipulate; pellets may be formed using the Lee MTA block (Fig. 21). Alternatively, MTA is placed using some form of micro-carrier system (Fig. 22). Excess material is removed using a periodontal curette or carver and the surface of the filling finished with a damp sponge or cotton pellet (Fig. 23).

Figure 21
figure21

Lee Block, useful for forming pellets of MTA

Figure 22
figure22

Micro-carriers for easier placement of MTA root-end filling

Figure 23
figure23

Completed MTA root-end filling

MTA is one of the few materials that were found to encourage the formation of cementum at the root-end surface.50,51 The formation of 'a double seal' incorporating both a physical and biological covering over the resected root end is a desired result of periradicular surgery.47 In the first randomised prospective clinical study on the use of MTA as a root-end filling material it was reported that the highest number of teeth with complete healing was observed with MTA.1 When the numbers of teeth with complete and incomplete (scar) healing were combined, although the results for MTA were higher (92%) compared with IRM (87%), there was no significant statistical difference in outcome between the two materials. The good results with both materials may be due to the strict entry requirements, the surgery carried out by specialists and the stringent, established criteria for assessing treatment outcome.

Recently a number of calcium silicate-based materials, such as Biodentine (Septodont, Saint-Maur-des-Fossés, France) and BioAggregate (Innovative BioCeramix, Vancouver, Canada), with similar properties to MTA have been marketed as alternatives. A drawback of Biodentine is that it is of similar radio-opacity to dentine, which makes it different to discern radiographically. It is anticipated that many new calcium silicate-based root-end filling material, formulated to overcome the disadvantages of MTA, will become available in due course.

Guided tissue regeneration procedures

The post-operative outcome for endodontic surgery is much poorer when there is loss of cortical bone overlying the root.13 Guided tissue regenerative procedures that are commonly used in periodontal surgery may be useful in endodontic surgery.52

Check radiographs

It is good practice to take a radiograph following placement of the root-end filling and before surgical closure. If necessary, any adjustments or revisions may be made without risking the need to re-access the surgical site.

The radiograph should show:

  • An adequate root-end resected and no remnants of the root tip

  • The root-end filling material well condensed and correctly adapted within the root-end cavity

  • No excess root-end filling material or other foreign bodies lodged in the bony crypt.

Flap replacement

The flap is gently eased back into place and gentle pressure applied using saline-moistened gauze to aid close approximation for flap re-attachment. Pressure is again applied for five to ten minutes after suturing to prevent haemorrhage occurring and to reduce the coagulum, a potential nidus for infection.53,54

Sutures

Sutures are required to hold the re-approximated tissue flap in position and prevent dislodgement allowing healing to occur by primary intention. Sutures may be braided or monofilament, absorbable or non-absorbable. Braided or multi-strand silk sutures can become infected with bacterial plaque through the 'wicking' effect so they are no longer recommended. Instead, single strand or monofilament sutures (Table 3) should be used (Fig. 24). According to operator preference the minimum number of interrupted or sling sutures required to retain the flap should be placed. Sutures are normally removed after 48-72 hours at which point early epithelialisation would have occurred.29,54

Table 3 Sutures types
Figure 24
figure24

Sutures: polyglactin 910 (top) and polypropylene (bottom)

Post-operative care

When surgery has been carried out efficiently with minimum trauma, post-operative healing is usually uneventful. Patients should be provided with post-operative instructions both verbally and in writing.7,8,55

Ice pack

The patient should be instructed to rest; strenuous activity should be avoided for at least 24 hours. An ice pack should be applied on the external area of the surgical site for two to four hours immediately following the procedure to help reduce the risk of swelling and resultant post-operative discomfort.55 Since the external area around the surgical site may still be numb it is important to warn the patient not to leave the ice pack in place for too long; intermittent application, 15-20 minutes on and 15–20 minutes off, should be adequate. The patient should also be instructed to avoid being overly inquisitive and retract the lip to have a look as this may dislodge the flap or apply unnecessary tension and pull out the sutures.

Wound care

Eating and drinking is best avoided while the area is still numb. Alcohol and smoking should be avoided. Tooth brushing can be omitted on the day of surgery, but recommenced the following day and in all areas apart from the surgical site. The cleanliness of the surgical site is maintained using chlorhexidine mouthwash; this is swilled for one minute, twice daily until the sutures are removed to help suppress plaque formation.56 Antibiotics are seldom required, should not be routinely prescribed and only indicated when there is, for example, suggestion of post-operative infection.

Pain and swelling

Although there may be mild discomfort following root-end surgery, severe pain is not usually a feature. The post-operative pain after root-end resection and filling is, normally, of a relatively short duration; it is at its maximum intensity early in the post-operative period, three to five hours afterwards, but progressively decreases with time.57 The maximum pain experienced is during the first day and the maximum swelling between the first and second day post-operative; patients with poor oral hygiene, smokers and those with pain before surgery may experience more pain and swelling.58

The benefit of pre-emptive analgesia has already been discussed and if practised should reduce the need for post-operative pain control. However, if necessary, post-operative pain can normally be controlled using NSAIDS such as Ibuprofen.55 Paracetamol may be used for patients unable to tolerate NSAIDS. Combining paracetamol and NSAIDS have also been shown to provide additive analgesia.59 Oral analgesics are more effective if taken regularly as this will ensure that a therapeutic dose of the drugs is maintained in the blood stream.

Bleeding

Excessive bleeding is unusual following surgery unless the flap or sutures have been dislodged. However, the patient may taste blood in their mouth and slight bleeding when mixed with saliva will always appear worse than it really is. An emergency telephone number should have been made available should the patient wish to make contact.

Bruising

Bruising can occur following surgery and is usually worse approximately three to four days following surgery. It may take some time to resolve and can look rather alarming even though the patient may not be in pain.

Endodontic surgery outcome

Within two to three days after surgery an initial review appointment is required to remove the sutures and assess healing. If healing is uneventful the patient may be seen again for another review 6-12 months later (Fig. 25); although at that stage the treatment outcome may be inconclusive. Longer follow-up periods may be necessary as there can be cases of favourable and unfavourable outcomes over time.9,60,61,62 The radiographic classification of treatment outcome following endodontic surgery described by Molven et al.63 is often used as there is good correlation with histological assessment. The four categories are:

  • Complete healing

  • Incomplete healing (scar)

  • Uncertain healing

  • Failure.

Figure 25: Maxillary central incisor.
figure25

(a) Radiograph showing extruded root filling material, which proved impossible to remove and tooth remained symptomatic even after non-surgical root canal retreatment; (b) Post-operative radiograph following periradicular surgery showing a well-adapted MTA root-end filling; (c) Recall radiograph six months post-surgery, evidence of bony healing and tooth is symptom-free

Some cases may initially appear to fall into the uncertain healing category but can, in due course, improve. Equally, late failures (>10 years) have been reported in cases that appeared to be initially responding well, although in this particular study64 the root-end filling material was amalgam.

Referrals

It is good practice to consider referring patients for endodontic surgery if it is better carried out by a colleague with specialist knowledge or training.65 Specialists in endodontics have spent many years training in microsurgical endodontic techniques and are best placed to help.66,67 A retrospective study on periradicular surgery carried out in endodontic and in oral surgery units of a teaching dental hospital reported a difference in the rate of complete healing in patients treated in the two different units.68 A recent meta-analysis of the literature concluded that the use of a microscope for endodontic surgery improves treatment outcome.69 Another meta-analysis concluded that treatment-related, patient-related, and tooth-related factors influenced the prognosis of periradicular surgery. The clinician may be able to control treatment-related factors but, unfortunately, not patient-related or tooth-related factors.70

Conclusions

In the past endodontic surgery was often viewed as a procedure of desperation and last resort with an unpredictable outcome. There was also limited understanding of endodontic disease and the causes of treatment failure. The concept that it is possible to confine microbes within the root canal system purely by placement of an apical plug, which led to poor case selection and the unquestioned practice of performing endodontic surgery first, is obsolete. The development of newer surgical armamentarium, the implementation of microsurgical techniques, the use of enhanced illumination and magnification, and the advent of newer root-end filling materials have revolutionised endodontic surgery (Table 4) and improved surgical outcome.

Table 4 Overview comparing older and newer periradicular surgery concepts and techniques

References

  1. 1

    Chong B S, Pitt Ford T R, Hudson MB . A prospective clinical study of Mineral Trioxide Aggregate and IRM when used as root end filling materials in endodontic surgery. Int Endod J 2003; 36: 520–526.

    Article  Google Scholar 

  2. 2

    Saunders W P . A prospective clinical study of periradicular surgery using Mineral Trioxide Aggregate as a root-end filling. J Endod 2008; 34: 660–665.

    Article  Google Scholar 

  3. 3

    Tsesis I, Faivishevsky, Kfir A, Rosen E . Outcome of surgical endodontic treatment performed by a modern technique: a meta-analysis of the literature. J Endod 2009; 35: 1505–1511.

    Article  Google Scholar 

  4. 4

    Setzer F C, Shah S B, Kohli M R, Karabucak B, Kim S . Outcome of endodontic surgery: A meta-analysis of the literature – Part 1: Comparison of traditional root-end surgery and endodontic microsurgery. J Endod 2010; 36: 1757–1765.

    Article  Google Scholar 

  5. 5

    Salehrabi R, Rotstein I . Epidemiologic evaluation of the outcomes of orthograde endodontic retreatment. J Endod 2010; 36: 790–792.

    Article  Google Scholar 

  6. 6

    Danin J, Strömberg T, Forsgren H, Linder L E, Ramsköld L O . Clinical management of nonhealing periradicular pathosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 213–217.

    Article  Google Scholar 

  7. 7

    Evans G E, Bishop K, Renton T . Guidelines for surgical endodontics. Version 2. London: Faculty of Dental Surgery, Royal College of Surgeons of England, 2012. Online guidelines available at http://www.rcseng.ac.uk/fds/publications-clinical-guidelines/clinical_guidelines/documents/surgical_endodontics_2012.pdf (accessed January 2014).

    Google Scholar 

  8. 8

    Chong B S . Managing endodontic failure in practice. London: Quintessence Publishing Co. Ltd., 2004.

  9. 9

    European Society of Endodontology. Quality guidelines for endodontic treatment: consensus report of the European Society of Endodontology. Int Endod J 2006; 39: 921–930.

  10. 10

    Use of cone-beam computed tomography in endodontics. Joint position statement of the American Association of Endodontists and the American Academy of Oral and Maxillofacial Radiology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 234–237.

  11. 11

    European Commission. Radiation protection No 172 cone beam CT for dental and maxillofacial radiology (evidence-based guidelines). SEDENTEXCT, 2011. Online guidelines available at http://www.sedentexct.eu/files/radiation_protection_172.pdf. (accessed January 2014).

  12. 12

    Müller H P, Eger T . Masticatory mucosa and periodontal phenotype: a review. Int J Periodontics Restorative Dent 2002; 22: 172–183.

    PubMed  Google Scholar 

  13. 13

    Dietrich T, Zunker P, Dietrich D, Bernimoulin J P . Apicomarginal defects in periradicular surgery: classification and diagnostic aspects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 233–239.

    Article  Google Scholar 

  14. 14

    Hauman C H, Chandler N P, Tong D C . Endodontic implications of the maxillary sinus: a review. Int Endod J 2002; 35: 127–141.

    Article  Google Scholar 

  15. 15

    García B, Martorell L, Martí E, Peñarrocha M . Periapical surgery of maxillary posterior teeth. A review of the literature. Med Oral Patol Oral Cir Bucal 2006; 11: E146–150.

    PubMed  Google Scholar 

  16. 16

    Rubenstein R . Magnification and illumination in apical surgery. Endod Topics 2005; 11: 56–77.

    Article  Google Scholar 

  17. 17

    Hargreaves K M, Khan A . Surgical preparation: anaesthesia and haemostasis. Endod Topics 2005; 11: 32–55.

    Article  Google Scholar 

  18. 18

    Dionne R A . Preemptive vs preventative analgesia: which approach improves clinical outcomes? Compend Contin Educ Dent 2000; 21: 51–54.

    Google Scholar 

  19. 19

    Jackson D L, Moore P A, Hargreaves K M . Preoperative nonsteroidal anti-inflammatory medication for the prevention of postoperative dental pain. J Am Dent Assoc 1989; 11: 641–647.

    Article  Google Scholar 

  20. 20

    Savage M G, Henry M A . Preoperative nonsteroidal anti-inflammatory agents: Review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 98: 146–152.

    Article  Google Scholar 

  21. 21

    Keiser K, Hargreaves K M . Building effective strategies for the management of endodontic pain. Endod Topics 2002; 3: 93–105.

    Article  Google Scholar 

  22. 22

    Martin M V, Nind D . Use of chlorhexidine gluconate for pre-operative disinfection of apicectomy sites. Br Dent J 1987; 162: 459–461.

    Article  Google Scholar 

  23. 23

    Tsesis I, Fuss Z, Lin S, Tilinger G, Peled M . Analysis of postoperative symptoms following surgical endodontic treatment. Quintessence Int 2003; 34: 756–760.

    PubMed  Google Scholar 

  24. 24

    Velvart P, Peters C I, Peters O A . Soft tissue management: flap design, incision, tissue elevation, and tissue retraction. Endod Topics 2005; 11: 78–97.

    Article  Google Scholar 

  25. 25

    von Arx T, Vinzens-Majaniemi T, Bürgin W, Jensen S S . Changes of periodontal parameters following apical surgery: a prospective clinical study of three incision techniques. Int Endod J 2007; 40: 959–969.

    Article  Google Scholar 

  26. 26

    Gutmann J L, Harrison J W . Surgical endodontics. St Louis, MO, USA: Ishiyaku EuroAmerica, 1994.

    Google Scholar 

  27. 27

    Velvart P . Papilla base incision: a new approach to recession-free healing of the interdental papilla after endodontic surgery. Int Endod J 2002; 35: 453–460.

    Article  Google Scholar 

  28. 28

    Velvart P, Ebner-Zimmermann U, Ebner J P . Comparison of papilla healing following sulcular full-thickness flap and papilla base flap in endodontic surgery. Int Endod J 2003; 36: 653–659.

    Article  Google Scholar 

  29. 29

    Luebke R G . Surgical endodontics. Dent Clin North Am 1974: 18: 379–391.

    PubMed  Google Scholar 

  30. 30

    Grung B . Healing of gingival mucoperiosteal flaps after marginal incision in apicoectomy procedures. Int J Oral Surg 1973: 2: 20–25.

    Article  Google Scholar 

  31. 31

    Byers M, Wheeler E F, Bothwell M . Altered expression of NGF and P75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting. Growth Factors 1992; 6: 41–52.

    Article  Google Scholar 

  32. 32

    Hoskinson A E . Hard tissue management: osseous access, curettage, biopsy and root isolation. Endod Topics 2005; 11: 98–113.

    Article  Google Scholar 

  33. 33

    Gilheany P A, Figdor D, Tyas M J . Apical dentin permeability and microleakage associated with root end resection and retrograde filling. J Endod 1994; 20: 22–26.

    Article  Google Scholar 

  34. 34

    Stropko J J, Doyon G E, Gutmann J L . Root-end management: resection, cavity preparation, and material placement. Endod Topics 2005; 11: 131–151.

    Article  Google Scholar 

  35. 35

    Rud J, Andreasen J O . Operative procedures in periapical surgery with contemporaneous root filling. Int J Oral Surg 1972; 1: 297–310.

    Article  Google Scholar 

  36. 36

    Chong B S, Pitt Ford T R, Kariyawasam S P . Tissue response to potential root-end filling materials in infected root canals. Int Endod J 1997; 30: 102–114.

    Article  Google Scholar 

  37. 37

    Tidmarsh B G, Arrowsmith M G . Dentinal Tubules at the root ends of apicected teeth: a scanning electron microscopic study. Int Endod J 1989; 22: 184–189.

    Article  Google Scholar 

  38. 38

    Chandler N P, Koshy S . The changing role of the apicectomy operation in dentistry. J R Coll Surg Edinb 2002; 47: 660–667.

    Google Scholar 

  39. 39

    Kim S, Pecora G, Rubinstein R A . Colour atlas of microsurgery in endodontics. London: WB Saunders, 2001.

    Google Scholar 

  40. 40

    Testori T, Capelli M, Milani S, Weinstein R L . Success and failure in periradicular surgery: a longitudinal retrospective analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 87: 493–498.

    Article  Google Scholar 

  41. 41

    Kim S, Kratchman S . Modern endodontic surgery concepts and practice: a review. J Endod 2006; 32: 601–623.

    Article  Google Scholar 

  42. 42

    Witherspoon D E, Gutmann J L . Haemostasis in periradicular surgery. Int Endod J 1996; 29: 135–149.

    Article  Google Scholar 

  43. 43

    Kim S, Rethnam S . Haemostasis in endodontic microsurgery. Dent Clin North Am 1997; 41: 499–511.

    PubMed  Google Scholar 

  44. 44

    Olson R A, Roberts D L, Osbon D B . A comparative study of polylactic acid, Gelfoam, and Surgicel in healing extraction sites. Oral Surg Oral Med Oral Pathol 1982; 53: 441–449.

    Article  Google Scholar 

  45. 45

    Ibarrola J L, Bjorenson J E, Austin B P, Gerstein H . Osseous reactions to three haemostatic agents. J Endod 1985: 11: 75–93.

    Article  Google Scholar 

  46. 46

    Jensen S S, Yazdi P M, Hjørting-Hansen E, Bosshardt DD, von Arx T . Haemostatic effect and tissue reactions of methods and agents used for haemorrhage control in apical surgery. Int Endod J 2010; 43: 57–63.

    Article  Google Scholar 

  47. 47

    Chong B S, Pitt Ford T R . Root-end filling materials: rationale and tissue response. Endod Topics 2005; 11: 114–130.

    Article  Google Scholar 

  48. 48

    Pitt Ford T R, Andreasen J O, Dorn S O, Kariyawasam S P . Effect of IRM root end fillings on healing after replantation. J Endod 1994; 20: 381–385.

    Article  Google Scholar 

  49. 49

    Chong B S . MTA- many tested applications. Dentistry 2001; 2: 18–20.

    Google Scholar 

  50. 50

    Torabinejad M, Pitt Ford T R, McKendry D J, Abedi H R, Miller D A, Kariyawasam S P . Histologic assessment of Mineral Trioxide Aggregate when used as a root end filling in monkeys. J Endod 1997; 23: 225–228.

    Article  Google Scholar 

  51. 51

    Baek, S H, Plenk Jr H, Kim S . Periapical tissue responses and cementum regeneration with amalgam, super-EBA and MTA as root-end filling materials. J Endod 2005; 31: 444–449.

    Article  Google Scholar 

  52. 52

    von Arx T, Cochran D L . Rationale for the application of the GTR principle using a barrier membrane in endodontic surgery: a proposal of classification and literature review. Int J Periodontics Restorative Dent 2001; 21: 127–139.

    PubMed  Google Scholar 

  53. 53

    Harrison J W, Jurosky K A . Wound healing in the tissues of the periodontium following periradicular surgery – 2: The dissectional wound. J Endod 1991; 17: 544–552.

    Article  Google Scholar 

  54. 54

    Velvart P, Peters C I, Peters O A . Soft tissue management: suturing and wound closure. Endod Topics 2005; 11: 179–195.

    Article  Google Scholar 

  55. 55

    Gutmann J L . Surgical endodontics: post-surgical care. Endod Topics 2005; 11: 196–205.

    Article  Google Scholar 

  56. 56

    Löe H, Schiott C R . The effect of mouthrinsesand topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Perio Res 1970; 5: 79–83.

    Article  Google Scholar 

  57. 57

    Chong B S, Pitt Ford T R . Postoperative pain after root-end resection and filling. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100: 762–766.

    Article  Google Scholar 

  58. 58

    García B, Larrazabal C, Peñarrocha M, Peñarrocha M . Pain and swelling in periapical surgery. A literature update. Med Oral Patol Oral Cir Bucal 2008; 13: E726–729.

    PubMed  Google Scholar 

  59. 59

    Breivik E, Barkvoll P, Skovlund E . Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind, single oral dose study. Clin Pharmacol Ther 1999; 66: 625–635.

    Article  Google Scholar 

  60. 60

    Molven O, Halse A, Grung B . Incomplete healing (scar tissue) after periapical surgery-radiographic findings 8 to 12 years after treatment. J Endod 1996; 22: 264–268.

    Article  Google Scholar 

  61. 61

    Zuolo M L, Ferreira M O, Gutmann J L . Prognosis in periradicular surgery: a clinical prospective study. Int Endod J 2000; 33: 91–98.

    Article  Google Scholar 

  62. 62

    Wang Q, Cheung G S, Ng R P . Survival of surgical endodontic treatment performed in a dental teaching hospital: a cohort study. Int Endod J 2004; 37: 764–775.

    Article  Google Scholar 

  63. 63

    Molven O, Halse A, Grung B . Observer strategy and the radiographic classification of healing after endodontic surgery. Int J Oral Maxillofac Surg 1987; 16: 432–439.

    Article  Google Scholar 

  64. 64

    Frank A L, Glick D H, Patterson S S, Weine F S . Long-term evaluation of surgically placed amalgam fillings. J Endod 1992; 18: 391–398.

    Article  Google Scholar 

  65. 65

    General Dental Council. Standards for the dental team. London: GDC, 2013. Online information available at https://www.gdc-uk.org/Dentalprofessionals/Standards/Documents/Standards%20for%20the%20Dental%20Team.pdf (accessed January 2014).

  66. 66

    General Dental Council. Curriculum for specialist training in endodontics. London: GDC, 2010. Online information available at http://www.gdc-uk.org/Dentalprofessionals/Specialistlist/Documents/EndodonticsCurriculum.pdf (accessed January 2014).

  67. 67

    Senate of Dental Specialties. Faculty of Dental Surgery, Royal College of Surgeons of England. Good practice in the dental specialties. London: RCS, 2004. Online information available at http://www.rcseng.ac.uk/publications/docs/dental_specialities.html (accessed January 2014).

  68. 68

    Rahbaran S, Gilthorpe M S, Harrison S D, Gulabivala K . Comparison of clinical outcome of periapical surgery in endodontic and oral surgery units of a teaching dental hospital: a retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 91: 700–709.

    Article  Google Scholar 

  69. 69

    Setzer F C, Kohli M R, Shah S B, Karabucak B, Kim S . A meta-analysis of the literature – Part 2: Comparison of endodontic microsurgical techniques with and without the use of higher magnification. J Endod 2012; 38: 1–10.

    Article  Google Scholar 

  70. 70

    von Arx T, Peñarrocha M, Jensen S . Prognostic factors in apical surgery with root-end filling: a meta-analysis. J Endod 2010; 36: 957–973.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to B. S. Chong.

Additional information

Refereed Paper

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chong, B., Rhodes, J. Endodontic surgery. Br Dent J 216, 281–290 (2014). https://doi.org/10.1038/sj.bdj.2014.220

Download citation

Further reading

Search

Quick links