Explains the structural weakening that occurs as a result of endodontic and restorative procedures.
Recognises fracture susceptibility in all endodontically treated teeth and the predisposition for damage in functioning roots.
Reflects upon the principles of cervical dentin preservation in stabilising load transfer to roots after endodontic procedures.
The primary goal of endodontic therapy is the long-term retention of a functional tooth by preventing or treating apical periodontitis. However, there are many other factors that impact endodontic outcomes such as the quality of the restoration and structural integrity of the tooth after root canal preparation. Contemporary research efforts are currently directed to better understanding dentin behaviour and structure during aging and function. An alternative approach is to minimise structural changes during root canal therapy, which may result in a new strategy that can be labelled 'minimally invasive endodontics'. This review addresses current clinical and laboratory data to provide an overview of this new endodontic paradigm.
Technological advances in optics, instrumentation, materials, robotics, and computer systems over the last decades have introduced new strategies and possibilities to the medical profession. These innovations are clearly beneficial to patients by dramatically improving morbidity and mortality outcomes associated with many surgical procedures.1
Compared to medicine, such a shift to a non-invasive approach to surgery in dentistry2 has been more moderate and cautious, perhaps with the exception of endodontic and periodontal microsurgery.3 It is difficult to directly compare operative procedures done to the human body versus those done on a tooth, however, a rational approach to dental procedures aiming to remove or reverse disease should be to conserve maximum structural integrity. This in turn has the potential to increase the functional prognosis for any given tooth.
The concept of minimally invasive endodontics calls for the treatment and prevention of pulpal pathoses and apical periodontitis, while causing the least amount of change to the dental hard tissues. This preserves the strength and function of the endodontically treated tooth with the intent that it will last the patient's lifetime.
Just as in medicine, the dental surgeon treating endodontic disease must develop new skills and dexterity in order to adapt to a limited working environment within the confines of the pulpal space. These skills include working with new instruments and irrigants for cleaning the system; utilising advanced imaging modalities and computer software for demonstrating both the complexities of the root canal system and improving the accuracy of techniques; employing increased magnification and lighting for visualising the pulpal space as well as applying new materials that enhance the prognosis for restoring structure and retaining the natural dentition.
There are, however, currently no developed protocols for minimally invasive endodontics. The aim of this review is to illustrate the current status of non-surgical endodontic procedures highlighting the conservation of tooth structure to enhance longevity after root canal treatment.
Preserving structural integrity
It is apparent that remaining structural integrity of the tooth (Fig. 1) is a key factor that determines prognosis as it relates to future function of the tooth after restoration.4,5 Maintaining strength and stiffness that resists structural deformation becomes the recognised goal of all restorative procedures, especially in endodontics. Appreciation for the biomechanical behaviour of dentin, as the limiting strength factor of any restorative complex, requires the recognition that dentin is weakened unequally by our restorative procedures.6
More than two decades ago a study was designed to compare the impact of endodontic versus restorative procedures on tooth strength. The stiffness of cusps was assessed when comparing traditional cavity preparations to endodontic access openings on bicuspid teeth. It was found that endodontic access openings by themselves have only a small (5%) impact on tooth stiffness as opposed to any restorative preparation that removes the tooth's marginal ridges (for example, a MOD preparation) reducing cuspal stiffness by 63%. The study identified approximately a 20% loss of tooth strength with each prepared surface. These findings highlight that marginal ridges are a key factor in retaining tooth strength.7
Another fundamental understanding of dentin behaviour within remaining structure comes with the abandonment of the widely held clinical perception that endodontically treated teeth are more brittle and hence more vulnerable to fracture. An early investigation that demonstrated moisture loss of 9% after root treatment in dog's teeth gave credence to this hypothesis.8 While animal models have some translation to humans, there is currently an abundance of studies in human teeth showing that the dentin properties of endodontically treated teeth do not differ in any meaningful way from vital dentin.9,10,11 Conversely, the predominant reason that endodontically treated teeth are more prone to fracture relates more than any other attribute to the structural loss of those root treated teeth requiring restoration. Collectively, these studies show minimal dehydration effects from pulpal removal and demonstrate biomechanical behaviours in strength and toughness testing that are similar to vital dentin.9,10,11
Unfortunately, structural loss alone cannot answer every clinical question that relates to dentin failure. The relevance of fatigue as a main mechanism for tooth fracture and the resistance of dental tissues to both the initiation and propagation of cracks is an important research area.12,13 Recently, investigations have focused on the impact of chemical factors such as irrigants and medicaments on dentin; the effects of bacteria on the matrix of dentin; structural loss; the effect of post and core restorations and the results of age changes in dentin.6,14 Of note, there is a reduction of up to 50% in the tensile strength and fatigue strength of coronal dentin in seniors (over 55 years) when compared to that of young adults. Similarly, the resistance to propagation of fatigue cracks in dentin decreases with increasing patient age and the incremental rate of crack extension is up to 100 times greater in seniors.15,16
Biomechanical behaviour of dentin
When endodontically treated teeth fail under function, that outcome is determined primarily by two aetiologies. Those causes stated most simply are: 1) the degree of stress experienced by the tooth under load, and 2) the inherent biomechanical properties of the remaining structure responsible for resisting fracture. It appears that, among technical elements of root canal therapy, access preparation and post preparation are most relevant in rendering the tooth more susceptible to significant destabilisation.17 Unfortunately, only a minimal number of long-term controlled clinical studies are available to assess the relationship between restoration, especially with posts, tooth fracture (Fig. 2) and the biomechanical behaviour of restored dentin. Within the limitations of bench top research, experimental evidence compels us to utilise 'best practices', yet our long-term data remains incomplete. The mechanical demands of human mastication create an endless number of impacting variables and only those long-term clinical outcomes remain the gold standard for evidence.
Teeth that physically fail through a vertical or unrestorable root fracture do not have to undergo endodontic treatment to experience this outcome. It has been demonstrated in the dental literature that all teeth, especially molars, can fracture without any endodontic treatment, and while some state this is not a common finding there are others who declare that the incidence is under-reported.18 However, when fracture occurs, it will inevitably have a devastating effect on both the periodontal attachment and the bone adjacent to the fracture. Once a fracture begins in the root and continues it is characterised by involvement of the root canal in the fracture progression; bacterial contamination of the failed section; food-debris, cements, necrotic tissue and bacteria; as well as inflammation associated with a reactive periodontium.19 Studies involving Chinese populations have reported that fractures may occur within teeth with vital pulps in individuals with excessive or repetitive oral chewing habits.18 This is in agreement with Yeh who also suggested heavy masticatory forces as a cause for root fracture.20 In addition, root fractures seem to be more prevalent in seniors and male populations; pre-existing attrition is often a component of the condition.18,21
Minimally invasive access strategies
Root canal anatomy and the complexity of human pulpal systems provide significant challenges for endodontic therapy. The first priority of effective therapy is to access, shape and clean the system in a manner that will allow efficient and total filling of the root canal space, while leaving the tooth with sufficient strength to function successfully.
For almost a century endodontic textbooks have taught the student of dentistry to expose the pulp chambers of teeth with 'straight-line' access to the orifice(s) of the root canal. Access cavities were to be prepared and expanded so that their smallest dimensions were dictated by the separation of the orifices on the pulpal floor and their widest dimensions were at the occlusal. In this era of enhanced lighting and magnification, as well as highly flexible rotary instruments, this approach to a doctrinaire access paradigm is being questioned as perhaps overly invasive of the tooth and an approach that may condemn a tooth to structural failure.22,23
Recently, maintaining structural integrity of the peri-cervical area of the tooth (about four mm above and below the alveolar crest) has been emphasised. Maintenance of the peri-cervical dentin (PCD), especially in molars is felt to be critical to their long-term survivability and optimum function.23 Some argue that in treatment planning for endodontics, on a molar tooth especially, clinicians must consider the significantly higher overall compressive forces that create a situation requiring a different set of rules for the calculation of ferrule, post and core design, resistance to fracturing, and most importantly, endodontic access (Fig. 3) and removal of radicular dentin during endodontic shaping.23
In keeping with this philosophy of minimal invasion of bulk dentin structure, the use of round burs and Gates-Glidden burs is now discouraged. While both of these types of instruments have been essential in endodontics for decades, they are now recognised in endodontic treatment as instruments that commonly gouge the endodontic access and the coronal third of the root canal (Fig. 4), those areas adjacent to the cemento-enamel junction (CEJ) of the tooth with critical structural prerequisites. Gouging of the access and coronal canal space must be avoided in order to preserve maximal resistance to structural flexure and ultimate failure.7,23 By directing the conservation of dentin and protecting dentin above and below the PCD the practitioner ensures a more viable and proven method to reinforce the endodontically treated tooth. No man-made material or technique can compensate for tooth structure lost in those key areas.
Shaping the root canal space
Root canals are sometimes depicted as smooth hollow tubes that are more or less tapered in shape. These misleading images do not reflect the intricate anatomical structure and complexity of root canal systems. They are often asymmetrical or oval in cross section, they branch, dilacerate and divide and the canal walls show concavities and convexities.24 Complex root canal anatomy should be considered one of the most significant challenges in creating root canal shapes that will support good obturation outcomes and leave sufficient remaining strength in the root. After biomechanical instrumentation, the completed root canal shapes need to withstand the internal compressive forces of obturation; provide sufficient resistance form to contain softened and compressible filling materials and retain enough strength for mastication (Fig. 5).
In a series of morphometric measurements on anterior and posterior teeth, Kerekes and Tronstad25,26,27 found a wide range of measurements at the apical constriction of all teeth, thus creating two separate philosophies for practitioners, each focused on its own set of evidence-based protocols supporting a position on how to clean these apical diameters and ultimately shape the root.
In another study that questioned our understanding of the true horizontal diameters necessary to clean the terminus, Jou et al.28 coined the term 'working width' to alert clinicians to the critical need to understand the horizontal dimension of apical size and its clinical implication in cleaning the apical terminus.
Consequently, current shaping strategies employed by today's clinicians align with two general trends in contemporary endodontic practice. A significant number of practitioners believe that enhanced apical instrumentation and larger apical diameters with minimal taper in the canal shape leads to weakening of the root structure and a loss of control over the obturation component of treatment. They advocate smaller apical preparations, continuous taper, and a preparation that promotes resistance form, a tight apical seal and a conservative approach to creating sufficient shape for adequate disinfection (Fig. 6). Smaller apical sizes preserve dentin. The arguments are strategic and technique-driven, albeit often supported by inferred outcomes. The impetus for smaller apical sizes has been directed at the disinfection and obturation phase of endodontic therapy.29,30,31,32
On the other hand, there is a significant body of literature that presents evidence that larger apical canal diameters (Fig. 7) are important to shape the apical canal wall, flush debris, allow deeper irrigation to the terminus and decrease remaining bacterial contamination in the system.33,34,35,36,37,38 Studies vary on which size diameter will accomplish maximum cleaning. Some researchers have suggested file diameters ranging from #35-#45 to accomplish significant bacterial reduction. Others have shown that minimal sizes can accomplish this task as adequately as larger diameters.40,41 What is remarkably clear from the evidence is that no matter which school of thought one ascribes to, it is not possible that any apical preparation technique will render the terminus entirely free of bacterial contamination in an infected canal.24,42 In essence, structural considerations in shaping continue to remain a compelling argument for conservative shapes.
Weine et al.43 and others44,45 have described and elucidated the structural damage and preparation errors that can occur while shaping root canals with stainless steel instruments to large sizes. Transportation, ledging, apical perforation and loss of the original canal position are all well recognised shaping errors that often lead to loss of working length, ledging and damage to the apical terminus leading to weakening of the root structure at its most fragile levels.
There is now a large body of conclusive research quantifying the use of rotary and hand nickel-titanium instruments first described by Walia,46 who report that the use of this super-elastic metal alloy offers less straightening and better centered preparations compared to traditional stainless steel instruments in preparing the wide range of anatomical variability seen in teeth.47,48,49,50,51,52
These studies have focused on the geometry of shape produced by these instruments alone or in combination with stainless steel; including conicity, taper, flow and maintenance of original canal position. Most of these studies have recorded the degree of change from original position and have measured the loss of original canal positions based on the definitions by Weine.43 In comparing stainless steel versus nickel-titanium, researchers have focused on both the metallurgy of the systems and the systems themselves.52,53 Collectively these studies suggest that Nickel-titanium technology alone or in combination with the conservative use of stainless steel instruments provides shapes that are better centered, maintaining the original canal positions with greater conservation of dentin and safer radicular preparations.
Disinfection and other considerations in minimally invasive endodontics
In order to address the microbiologic aetiology of endodontic disease, that is, periapical inflammation, disinfection is and will always remain, a key element of the overall treatment strategy. At first glance, any minimally invasive approach to root canal treatment is at conflict with disinfection. Microbiological studies in vitro, however, do not provide a definitive answer as to the required preparation size for antimicrobial efficacy. Table 1 shows selected studies suggesting a wide range of apical sizes. More recently a clinical study rekindled the notion of a preparation 'three sizes larger than the initial size';66 however, a large clinical data set does not support any particular canal shape as being associated with apical healing67 or retention of a root canal-treated tooth.68
Current cleaning and shaping methods appear to be unlikely to predictably remove all bio-burden from the root canal system. Therefore, and particularly under the conditions of smaller apical preparation sizes, the search continues for techniques to enhance irrigation efficacy. The possibilities for physical means that enable enhanced disinfection vary from ultrasonic or sonic activation up to and including laser activation.69,70,71
In the absence of adequate models for clinical outcomes, only direct clinical studies assessing both apical bone fill and tooth function/survival will provide convincing evidence regarding canal disinfection efficacy.
The effect of a modified access cavity design has only recently been tested in extracted teeth. Using a combined micro-computed tomography and load-to-failure approach, Krishan et al.72 found that in premolars shaping was not impacted and load to failure was significantly higher for teeth with minimal access cavity designs.
While the idea of minimally invasive endodontics has been promoted recently, there is a scarcity of independent evaluations for such a strategy. For example, root canal preparation instruments sometimes associated with this strategy such as V-Taper (SS White, Lakewood, NJ, USA) and Endo-EZE AET (Ultradent, South Jordan UT, USA) have not been shown to actually perform in a superior way to traditional rotary instrumentation in the laboratory.73,74
Another aspect of this discussion is the finding of micro-cracks induced by various rotary shaping procedures in canal preparation. In recent years several investigations have illustrated such micro-cracks in extracted teeth.75,76 While it is not clear at this point if such cracks are generated in vivo, it may be reasonable to develop instruments that reduce vibration and rotational stresses during intracanal procedures in an effort to lessen additional loads on a structurally weakened root.
Micro-computed tomography studies not only show overall canal shaping outcomes47,48,49,50,51,52 but have also demonstrated that hard tissue debris is compacted into unshaped canal areas rendering them potentially inaccessible to irrigation.77 It is likely future root canal preparation techniques will have to focus on balancing disinfection capacity and iatrogenic damage with enhanced debridement and disinfection.
Restoration strategies for maximum protection and minimal invasion
Patients are not well served if the endodontic treatment is successful but the tooth fails, especially with the emergence of implants into the mainstream of dentistry and their choice as an alternative to saving the natural dentition.78 In extensive reviews of evidence surrounding the restoration of endodontically treated teeth, preserving intact coronal and radicular tooth structure, especially maintaining the peri-cervical structure to allow a substantial 'ferrule effect', is considered to be crucial for the optimal biomechanical behaviour of restored teeth.79,80 Encircling the parallel walls of remaining dentin with the crown margin allows a ferrule that provides a protective effect by reducing stresses within a tooth. The presence of a 1.5 to 2 mm ferrule has a positive effect on fracture resistance of endodontically treated teeth.81,82,83,84 Teeth with a ferrule of one mm of vertical tooth structure doubled the resistance to fracture compared with teeth restored without a ferrule.82 Even if the clinical situation does not permit a circumferential ferrule, an incomplete ferrule is considered a better option than a complete lack of ferrule.85,86 However, it can be generally concluded that providing an adequate ferrule lessens the destabilising impact of the post and core system85,87,88 and the final restoration81 in the long-term performance of restored root treated teeth.
When it comes to severely damaged teeth with little or no coronal structure, in order to provide space for a ferrule, orthodontic extrusion should be considered rather than surgical crown lengthening. This approach preserves more tooth structure and ensures a more favourable biomechanical behaviour of remaining dentin structure.89,90 If neither of the alternative methods for providing a ferrule for the restoration can be performed, currently available evidence suggests that a poor treatment outcome and the ultimate the loss of the tooth has a high probability.5,82,91,92
Is root strengthening a possibility?
The past decade has seen a considerable change in clinical strategies for using and placing posts. An advancing principle promoting minimally invasive therapy directs the nominal use of posts in endodontically treated teeth. That principle, based on evidence, affirms that retaining tooth structure is more valuable than the use of a post in almost every circumstance where adequate structure exists for a ferrule.93,94 The long-term success of endodontic treatment has always been highly dependent on the restorative treatment that follows. A restored tooth must be structurally sound and the sealed state of the root canal system must be maintained. Most endodontically treated teeth today are restored with adhesive materials. Adhesive bonding provides an immediate seal of the pulpal spaces and some immediate toughening of the tooth. These materials are generally not dependent on gross mechanical retention, so tooth structure can be preserved and these materials can certainly be termed minimally invasive (Fig. 8).
Conventional thought has been that posts do not 'reinforce' the root. Early restorative protocols considered this true for metal posts, but there is now a growing body of evidence that bonded fibre posts can be placed with no removal of dentin structure, may protect the root and make it more resistant to fracture. Fibre-reinforced resin posts were introduced over 20 years ago with the intent to provide more elastic support to the core. The reduced stress transfer to tooth structure lowered the likelihood of root fracture. In addition, posts made of materials with a modulus of elasticity similar to dentin were considered more resilient; able to absorb similar impact forces, and distribute the forces of mastication in a more protective manner to remaining dentin than stiffer metallic posts.78,94 Based on the aforementioned evidence, it may be premature to describe adhesive technology as 'reinforcing' or 'root strengthening' but in terms of distributing forces throughout the remaining dentin structure it may certainly be deemed 'protective'.
The causes for post-treatment loss of teeth after endodontic therapy, when the therapy itself has been successful, have been described in this article by citing many diverse authorities. The loss of a tooth after successful endodontic therapy can invariably be attributed to one or more predictable explanations.
Often these sequelae are clinically avoidable and the result of an approach to therapy that is far more invasive than required to remove and cure the causes of apical periodontitis. These outcomes include:
Poor access cavity design and execution
An iatrogenic or procedural mishap weakening peri-cervical integrity
Instrumentation errors such a ledging, perforation, transportation from centre
Coronal leakage and recontamination of the pulpal space
Crown and root fracture.
As practitioners of the art and science of dentistry, poor outcomes in the course of endodontic treatment should encourage reflection on the careful and prudent practice of endodontics that safeguards against undesired consequences. Our obligation as experts is to protect patients from iatrogenic harm. This responsibility is met when we as a profession can provide advanced and sophisticated therapies in a safe and controlled manner with preservation of the dentition as an overriding priority in all aspects of our treatments.
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Gluskin, A., Peters, C. & Peters, O. Minimally invasive endodontics: challenging prevailing paradigms. Br Dent J 216, 347–353 (2014). https://doi.org/10.1038/sj.bdj.2014.201
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