Table 2 Summary of top hits for each shape, YAP/TAZ ratio, total YAP/TAZ for MDA-MB-231 ONTARGETPlus and siGENOME screens.

From: RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer

  Gene Name GeneID MDA-MB-231 ONTARGET Plus MDA-MB-231 siGENOME
    Fold Change Z-score Fold Change Z-score
Spindly DOCK5 80005 2.78 8.70 1.62 2.57*
Large, spread ECT2 1894 5.47 7.83 8.64 10.7*
Triangular MCF2 4168 1.54 5.14 0.97 0.40
Fan ECT2 1894 3.15 6.98 3.02 7.58*
Small, round ARHGEF18 23370 1.57 4.01 0.48 −4.45
YAP/TAZ ratio
 High PIK3R2 5296 1.67 5.67 0.85 −1.34
 Low MYO9B 4650 0.62 −3.39 0.73 −2.84*
Total YAP/TAZ
 High FARP1 10160 1.31 1.93 1.60 4.19*
 Low PIK3R2 5296 0.61 −5.46 0.74 −3.41*
  1. Top hits were chosen from the ONTARGETPlus library. Hits considered to be common across siRNA libraries are denoted by an asterisk.