Table 1 Summary of top hits for each shape, YAP/TAZ ratio, and total YAP/TAZ for LM2 ONTARGETPlus and siGENOME screens.

From: RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer

  Gene Name Gene ID LM2 ONTARGET Plus LM2 siGENOME
    Fold Change Z-score Fold Change Z-score
Spindly FAM13A 10144 3.13 10.6 2.61 6.97*
Large, spread ECT2 1894 7.25 16.0 7.66 11.6*
Triangular TRIO 7204 1.46 3.35 1.65 2.66*
Fan TRIO 7204 2.58 3.29 1.27 1.13
Small, round ARHGAP5 394 2.35 8.03 1.12 0.51
YAP/TAZ ratio
 High ARHGEF15 22899 1.12 3.73 1.12 2.17*
 Low ARHGAP33 /SNX26 115703 0.48 −5.65 0.86 −2.94*
Total YAP/TAZ
 High NET1 10276 1.40 3.45 1.19 0.99
 Low MCF2 4168 0.38 −7.85 0.79 −2.38*
  1. Top hits were chosen from the ONTARGETPlus library. Hits considered to be common across siRNA libraries are denoted by an asterisk.