Table 5: Summary of coding variant frequencies in the WES panel.

From: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Variant Frequency All samples African-American East-Asian European Hispanic South-Asian
Rare (MAF<0.5%) 95.79% 83.30% 90.06% 89.19% 84.56% 89.89%
private 77.93% 53.79% 65.47% 51.80% 37.26% 61.55%
cosmopolitan 0.35% 1.80% 3.02% 1.88% 2.24% 1.73%
Low frequency (0.5%<MAF<5%) 2.57% 10.36% 4.61% 5.52% 8.21% 5.10%
private 0.17% 1.43% 1.10% 0.26% 0.52% 1.02%
cosmopolitan 0.60% 1.50% 1.54% 1.94% 2.74% 1.62%
Common (MAF>5%) 1.65% 6.35% 5.33% 5.29% 7.23% 5.00%
private 0.09% 0.00% 0.00% 0.00% 0.01% 0.00%
cosmopolitan 1.50% 4.35% 5.17% 4.97% 6.88% 4.86%
  1. Shown are aggregate frequency statistics on coding variants in the WES panel, stratified by frequency. Counts and frequencies are shown for variants specific to each ancestry, as well as overall. Private: unique to one ancestry group; Cosmopolitan: observed across all ancestry groups. Adapted from Extended Data Table 2 in Fuchsberger et al.8.