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Priapism in acute spinal cord injury

Abstract

Study design:

Prospective literature review; search via Oldmedline (1958–1965), Medline (1966–2005) and Pubmed.

Objectives:

The objective of this study is to review the pathophysiology of priapism in acute traumatic spinal cord injury (SCI); to determine the incidence of priapism in traumatic SCI, whether or not priapism is associated with incomplete or only complete SCI and whether and what treatment might be required.

Methods:

This is a review article based upon the available literature in this area.

Results and conclusions:

Priapism that follows acute traumatic SCI is high-flow (non-ischaemic) priapism, that is, the blood within the corpus is arterial in nature. Priapism does not occur in all patients with acute SCI. The literature does not allow us to determine in what proportion of patients priapism occurs. Priapism has been reported following a wide variety of spinal cord pathologies including acute SCI, transverse myelitis and postoperative extradural haematoma. In all patients, priapism is associated with complete motor and sensory (American Spinal Injury Association A) paraplegia. Priapism has been reported following spinal shock. Following traumatic SCI, priapism usually settles rapidly without specific treatment being required. Priapism occurs at the moment of complete motor and sensory paraplegia, it does not occur following a delay. There are medicolegal implications: the presence/absence of priapism assists in determining when the complete spinal cord lesion occurred.

Introduction

Priapism is persistent erection of the penis.1 In females, persistent erection of the clitoris is known as clitorism.2 The frequency and timing of priapism in acute spinal cord injury (SCI) and the level, or levels, most likely to be associated with priapism are debated.

Methods

A literature search was performed on Oldmedline (1950–1965), Medline (1966–2005) and Pubmed. The search terms were priapism, penile erection or clitorism plus spinal injury. The search was English language not restricted by time. The primary references were reviewed and supplementary references were taken from the primary source references.

Results

There is a very restricted literature that has reported priapism in patients with SCI. Gordon et al.3 reported six patients with priapism following acute SCI; all six had a complete (American Spinal Injury Association A) spinal cord lesion. Rodi et al.4 reported a 42-year-old man undergoing posterior spinal fixation for a fracture of L2 associated with ankylosing spondylitis. The patient awoke with priapism and with a complete motor and sensory paraplegia that was a consequence of a large epidural haematoma. The haematoma was decompressed as an emergency, the motor and sensory paraplegia and priapism resolved rapidly. Priapism has been reported following spinal shock, that is, it has been reported in what initially appeared to be a complete spinal cord lesion; the spinal cord lesion resolved.5

Other lesions affecting the spinal cord or the cauda equina nerve roots can also cause priapism. Priapism has been reported in patients with spinal stenosis,6 sacral tumours,7, 8 transverse myelitis,9 epidural haematoma,4, 10 transurethral surgery11 or spinal anaesthesia.12

Following judicial hanging in men, there may be a complete or partial penile erection with or without ejaculation (the terminal, or death, erection).13 Priapism has also been associated with fatal gunshot wounds to the brainstem or spinal cord.14

Discussion

Classification of priapism

Priapism has been subdivided into two types: (1) low-flow (ischaemic) or (2) high-flow (non-ischaemic).1 Low-flow priapism is more common; typically the penile shaft is firm, the glans penis is soft and the priapism is painful. The causes of low-flow priapism include haematological disorders such as leukaemia,15 sickle cell anaemia16 or diffuse intravascular coagulation,17 drugs6 or pelvic malignancy.8 Blood sampled from the corpus is venous, in appearance and on blood gas analysis.3

High-flow priapism is typically caused by injury; injury can be to the perineum1 or to the spinal cord.3 Other causes of spinal cord dysfunction including spinal stenosis,10 sacral tumours,7, 8 transverse myelitis,9 epidural haematoma,4 transurethral surgery11 or spinal anaesthesia12 can, rarely, cause high-flow priapism. In high-flow priapism the penis is usually painless; blood sampled from the corpus is arterial, in appearance and upon blood gas analysis.3

Mechanisms

It is assumed that the mechanism of priapism in most patients with SCI is that abrupt loss of sympathetic input to the pelvic vasculature leads to increased parasympathetic input and uncontrolled arterial inflow directly into the penile sinusoidal spaces.18 The majority of spinal cord lesions that are associated with priapism are located in the cervical region, but the lesion can be at any level in the spine. In Gordon et al's3 six patients, five had cervical lesions and one had a lesion at T12. In Hammond et al's9 three infants with transverse myelitis, all three had cervical cord lesions. The sympathetic outflow arises from the thoracolumbar spine, that is, the spinal cord from approximately T2 to the conus (L1-2). The sympathetic outflow to the penis and clitoris arises from the lowest levels of the spinal cord, the conus, which is the reason why a lesion at any level in the spinal cord from the brainstem to the conus can be associated with priapism.

Priapism appears invariably to be associated with a complete spinal cord lesion regardless of the aetiology of the complete cord lesion. In Gordon's3 six patients with traumatic SCI, and Hammond and Kerr's9 three male infants with transverse myelitis, all patients had an (American Spinal Injury Association A) complete motor and sensory paraplegia. If a patient is unconscious because of a traumatic brain injury, priapism is an indication of coexisting SCI.19

A SCI that, on clinical examination, is complete can be anatomical, that is, there is physical damage to the motor and sensory pathways in the spinal cord, or it can be physiological (spinal shock). Spinal shock is a physiological cause of traumatic motor and sensory paralysis, which is reversible (typically over several hours or days). Priapism has been reported following spinal shock.5 Spinal shock is rare; most patients with traumatic SCI who have complete motor and sensory paraplegia on first assessment have irreversible lesions, which is the reason why the presence of priapism usually carries a poor prognosis for neurological or functional recovery.

Priapism, if it occurs, is normally present at first assessment,3 that is, if it occurs it happens rapidly following a complete spinal cord lesion. Where erection occurs following judicial hanging, it occurs at the point of execution, not subsequently. It is reasonable to assume that in SCI patients who have priapism, it occurs at the moment of, or very shortly after, the complete spinal cord lesion.

Not all men with complete SCI develop priapism. It is not known in what proportion of men with a complete spinal cord lesion does priapism occurs.

Evidence from judicial hanging

Following judicial hanging in men, there may be a complete or partial erection with or without ejaculation (the terminal or death erection).13 Judicial hanging was thought to cause death via spinal cord and/or brainstem injury secondary to fracture and/or dislocation of the cervical spine.20, 21, 22, 23 However, post-mortem examination of 34 cases of execution by judicial hanging (1882–1945) demonstrated an axis (‘hangman's’) fracture in only 6 cases (18%) and cervical fracture in only 1 case.24 In those persons (the majority) who have no cervical fracture following judicial hanging, it is probable that loss of consciousness and death are the consequences of lacerations to, and haemorrhage from, the carotid or vertebral arteries.25, 26, 27, 28

Treatment of priapism

Ischaemic (low-flow) priapism can be a medical emergency. Treatment with alpha-agonists or corporal aspiration of blood is usually required as an emergency to prevent corporal fibrosis and long-term erectile dysfunction. High-flow (non-ischaemic) priapism can usually be managed conservatively.3 Rarely, endovascular occlusion of the dilated penile vessels may be required.29

Priapism in acute traumatic SCI is a short-lasting phenomenon, which must be distinguished from recurrent or refractory priapism that can occur in patients with chronic SCI.30 Once priapism has occurred (following acute traumatic SCI) it usually settles rapidly. In Gordon et al's3 six patients with post-SCI priapism, four were treated conservatively and the erection settled spontaneously within 5 h in all cases. The author has seen one case of persistent priapism 24 h after complete SCI, which resolved without specific treatment.

Medicolegal implications

There are implications, medicolegally, in determining the timing and causation of SCI. Injury to the spinal column (fractures and/or dislocations) may be associated with immediate SCI, incomplete or complete. In others there may be injury to the spinal column, which is not associated with any neurological deficit. Patients with potentially unstable injuries to the spinal column must be transferred, transported and examined with in-line spinal immobilisation to prevent excessive movement at the level of an unstable injury. If excess movement at the level of an unstable fracture or dislocation is not prevented, there can be secondary damage to the spinal cord, which could lead to the patient with no initial SCI developing an incomplete or complete SCI that was potentially preventable (or a patient with an incomplete SCI becoming complete). Secondary deterioration of neurological function in patients with SCI is uncommon, occurring in about 4% of patients.31, 32, 33 It is probable that in the great majority of patients, secondary neurological deterioration is associated with excess movement at the level of an unstable fracture and/or dislocation.34, 35, 36, 37

Some men with acute SCI never develop priapism. For those that do: if, at the time of first assessment (perhaps by lay people, ambulance paramedics or A&E staff) priapism is present then we can conclude (in the absence of any further neurological information) that, on a balance of probabilities, the injury to the spinal cord occurred within the past few hours and the spinal cord lesion was complete at the time of those first observations. If, however, on first assessment there was no penile erection and priapism was subsequently identified then, on a balance of probabilities, the complete SCI was not a consequence of the primary injury, but occurred subsequently. As set out above, the overwhelmingly most likely cause of secondary SCI is excessive movement at the level of an unstable fracture and/or dislocation.

Conclusions

Priapism occurs in a proportion of men with acute traumatic SCI. The proportion of men with acute SCI that develop priapism is not known. Priapism can be associated with injury to any part of the spinal cord from the foramen magnum to the conus. A turgid semi-erect or erect priapism is always associated with a complete (American Spinal Injury Association A) motor and sensory paraplegia. Priapism probably occurs at the moment of, or very shortly after, complete SCI. This is high-flow (arterial) priapism. The priapism settles spontaneously usually within a few hours, occasionally up to 30 h after the SCI. It, only, rarely requires medical treatment. There are medicolegal implications: if priapism was not present in the pre-hospital or initial hospital phases of management but priapism and complete motor and sensory paraplegia were subsequently identified, the complete SCI may have been a consequence of failure to immobilise the spine during the pre-hospital or early hospital care.

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Todd, N. Priapism in acute spinal cord injury. Spinal Cord 49, 1033–1035 (2011). https://doi.org/10.1038/sc.2011.57

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Keywords

  • priapism
  • spinal cord injury
  • complete cord lesion
  • incomplete cord lesion.

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