Table 2 Multivariate analysis of factors and UDI-6 at different time points in SCI patients with detrusor BoNT-A injection

From: Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia

Variable Cases UDI-6 P-valuea
   Baseline 3 months 6 months  
Level of injury
 C-spine 13 10.5±3.5 6.5±4.0 5.4±2.3 0.995 (3 months vs BL)
 T-spine 19 11.6±3.6 8.7±4.0 10.2±4.4 0.22 (6 months vs BL)
 L-spine 6 12.5±4.1 7.2±4.0 9±4.2  
Baseline Pdet
 Pdet 40 17 10.5±2.7 6.4±4.4 8.7±4.9 0.86 (3 months vs BL)
 Pdet > 40 21 12.1±4.1 8.7±3.5 8.3±3.8 0.82 (6 months vs BL)
Baseline DSD type
 Type 1 14 11.6±3.3 7.4±3.3 8.8±4.5 0.22 (3 months vs BL)
 Type 2 14 9.9±2.7 7.9±4.5 8.1±4.9 0.22 (6 months vs BL)
 Type 3 10 11.3±4.6 8.4±4.7 8.6±4.2  
Baseline PVR
100 20 11.5±3.6 8.1±4.1 8.1±4.6 0.89 (3 months vs BL)
 >100 18 11.2±3.6 7.3±4.0 8.9±4.0 0.53 (6 months vs BL)
Gender
 Male 17 10.5±3.6 8.2±4.3 9.5±4.4 0.53 (3 months vs BL)
 Female 21 12.1±3.5 7.4±4.2 8.9±4.5 0.602 (6 months vs BL)
Compliance
30 27 12.1±3.1 8.2±4.3 9.5±4.4 0.77 (3 months vs BL)
>30 11 9.6±4.3 6.6±3.3 6±2.9 0.76 (6 months vs BL)
ASIA scale
 Non-A 12 12.4±3.6 7.8±3.9 10.3±3.7 0.19 (3 months vs BL)
 A 26 10.9±3.6 7.7±4.2 7.7±4.3 0.48 (6 months vs BL)
Dosage
 200 U 11 13.1±3.9 9.6±3.8 10.6±4.3 0.6 (3 months vs BL)
 300 U 11 10.6±4.4 7.5±3.4 9.2±3.9 0.359 (6 months vs BL)
  1. Abbreviations: ASIA, American Spinal Injury Association; BL, baseline; BoNT-A, botulinum toxin A; DSD, detrusor sphincter dyssynergia; Pdet.Qmax, detrusor pressure at maximum ow rate; PVR, post-void residual; UDI-6, urogenital distress inventory 6-item short form.
  2. aP-value using paired Student's t-tests for dichotomous variables and analysis of variance for more than two variables to compare changes of UDI-6 among patients with different variables.