Acute management of traumatic spinal cord injury in a Greek and a Swedish region: a prospective, population-based study

Abstract

Study design:

Prospective, population-based study. This paper is part of the Stockholm Thessaloniki Acute Traumatic Spinal Cord Injury Study (STATSCIS).

Objectives:

To characterize patient populations and to compare acute management after traumatic spinal cord injury (TSCI).

Settings:

The Greater Thessaloniki region in Greece and the Greater Stockholm region in Sweden.

Methods:

Inception cohorts with acute TSCI that were hospitalized during the study period, that is September 2006 to October 2007, were identified. Overall, 81 out of 87 cases consented to inclusion in Thessaloniki and 47 out of 49 in Stockholm. Data from Thessaloniki were collected through physical examinations, medical record reviews and communication with TSCI cases and medical teams. Data from Stockholm were retrieved from the Nordic Spinal Cord Injury Registry.

Results:

There were no significant differences between study groups with regard to core clinical characteristics. In contrast, there were significant differences in (1) transfer logistics from the scene of trauma to a tertiary-level hospital (number of intermediate admissions, modes of transportation and duration of transfer) and (2) acute key therapeutic interventions, that is, the use of mechanical ventilation (49% in Thessaloniki versus 20% in Stockholm), and performance of tracheostomy (36% in Thessaloniki versus 15% in Stockholm); spinal surgery was performed significantly more often and earlier in Stockholm than in Thessaloniki.

Conclusions:

Despite largely similar core clinical characteristics, Stockholm and Thessaloniki cases underwent significantly different acute management, most probably to be attributed to adaptations to the differing regional approaches of care one following a systematic approach of SCI care and the other not.

Introduction

This paper presents part of a comparative study on traumatic spinal cord injury (TSCI), the so-called Stockholm Thessaloniki Acute Traumatic Spinal Cord Injury Study (STATSCIS), in two European Union countries, namely Greece and Sweden.

Traumatic SCI management during the first days post-trauma has been addressed in several clinical and experimental studies.1, 2 Acute TSCI management starts at the scene of trauma, with the aim of limiting the extent of injury, handling its acute consequences, and preventing complications.3 Managing TSCI in spinal injury units (SIUs) as compared with fragmented care in general health-care facilities has been shown to be of benefit.4, 5, 6 While Sweden has six SIUs, TSCI in Greece is managed in various non-specialized surgical and orthopaedic wards.

The Consortium for Spinal Cord Medicine has recently compiled a Clinical Practice Guideline for Health-Care Professionals, the so-called ‘Early acute management in adults with spinal cord injury’.3 This publication underscores the importance of adequate acute management for the achievement of optimal outcomes.

Both prompt and correct diagnosis of TSCI is crucial for subsequent management. Accurate clinical examination according to the International Standards for Neurological Classification for Spinal Cord Injury7 is also highly relevant, especially during the acute phase, as it contributes to decision making.

We have previously presented the demographic and epidemiological characteristics of the two study cohorts in Thessaloniki and Stockholm.8 The aim of this second paper is specifically to assess clinical characteristics and acute management in the regions under study.

Materials and methods

A detailed description of the methodology of STATSCIS has been previously published.8

Settings

The ‘Greater Thessaloniki region’ (Thessaloniki) comprises Central and West Macedonia in Greece, whereas the ‘Greater Stockholm region’ (Stockholm) comprises Stockholm and Gotland Counties in Sweden. The two regions have a similar population size of 2 million, with Thessaloniki being about three times larger area wise than Stockholm.

Inclusion criteria

All of the following criteria had to be satisfied for inclusion in both regions: (1) acute traumatic spinal cord or cauda equina lesion, (2) age 16 years at the time of injury, (3) inpatient care at a hospital of Thessaloniki or Stockholm at some time between September 2006 and October 2007, (4) survival for at least 7 days post trauma, (5) being resident of the country of the respective region and (6) case giving informed consent for STATSCIS.

Material

Overall, 81 out of 87 (93%) consecutive cases with acute TSCI in Thessaloniki and 47 out of 49 (95%) in Stockholm consented to participate in the study.

Data collection and analysis

To satisfy the aims of STATSCIS, we implemented the Nordic Spinal Cord Injury Registry (NSCIR) data set in Thessaloniki. In Stockholm, the NSCIR data set is routinely being used since many years. NSCIR comprises scientifically and clinically relevant data according to international standards.9

Each case was individually followed up during the first year after trauma. A subset of the NSCIR consisting of the Acute Form and the Neurological Assessment Form was used for this paper (http://www.nscic.se). Additional detailed data regarding the transfer from the scene of trauma to arrival at a tertiary-level hospital were documented (for example, intermediate transfers, modes of transportation and duration of transfer). Operational definitions of the terms are provided in Table 1.

Table 1 Operational definitions used in the study in cases where a single, internationally accepted definition is lacking

In brief, the subset of the Acute Form that was used in this study is divided into four parts, each including several variables: (1) pre-hospital phase (including date, location and external cause of injury), (2) clinical status and management at the first hospital of admission (including level of consciousness (LOC), other vital signs, method of spinal stabilization), (3) clinical status on arrival at the tertiary-level hospital (including LOC, ventilation, diagnosis of SCI, presence/diagnosis of spinal column injury, presence/location/severity of extra-spinal injuries, presence/diagnosis of comorbid spinal and non-spinal disorders) and (4) type and date of key therapeutic interventions (including mechanical ventilation, tracheostomy, corticosteroid treatment, anticoagulant prophylaxis, spinal treatment). In Thessaloniki, the first author (AD) scrutinized all available medical records and Emergency Medical System data, and communicated directly with all cases and medical teams. In Stockholm, all data were retrieved from the NSCIR database.

The Neurological Assessment Form included a full examination according to the International Standards for Neurological Classification for SCI.7 In Thessaloniki, all such examinations for this study were performed by AD. This strategy was followed, as the International Standards were not universally implemented in Greece at the time of the study. AD has 8 years of clinical experience in SCI management, has participated in an official workshop on International Standards examination and has been using this assessment method for several years. The corresponding examinations in Stockholm were performed by physicians and physiotherapists specialized in SCI. For this study, comprehensive neurological examination on admission was performed at a mean time of 20 days after trauma (median=11, s.d.=±19.7) in Thessaloniki and 17 days (median=13, s.d.=±17.2) in Stockholm.

To maximize validity and minimize missing data, quality assurance was performed in both regions, that is, by cross-checking data in the registry forms with medical records. All retrieved data were jointly re-evaluated in detail by the authors for medical accuracy and uniform interpretation, for example, with regard to assessment of surgical procedures, extra-spinal injuries and any secondary morbidity.

Descriptive data are presented as n (%), mean, median and s.d. Statistical significance was set at P<0.05. Differences in proportions between regions were examined by χ2-test and Fisher's exact test. Statistical mean differences between regions were determined by independent Student's t-test. For ordinal variables or in cases of non-normal distribution, the Mann–Whitney test was used. All statistical analyses were performed using the SPSS software (Statistical Package for the Social Sciences, v. 16.0, Chicago, IL, USA).

Ethics

Ethical approvals for STATSCIS were obtained by the Human Ethics Committee at Karolinska Institutet, the Hellenic Data Protection Authority, the Nordic SCI Council, the Scientific Committee and the Board of each participating hospital in Thessaloniki.

Results

Transfer from the scene of trauma to a tertiary-level hospital

Cases who were injured outside the respective country under study were excluded from these particular analyses (Table 2). This occurred in six Swedish cases and in none of the Greek cases. In Thessaloniki, transfers were carried out either by road ambulance or by private cars, whereas in Stockholm, air transport was additionally used on nine occasions. Statistically, there were significantly more intermediate admissions in the Greek group, 33 to 1 hospital (41%) and 12 (15%) to 2 hospitals, than in the Swedish group, 7 (17%) to 1 hospital. The mean (s.d.) duration of transfer from the scene of trauma to a tertiary-level hospital was 2 days (±8.1) in Thessaloniki and 0.2 days (±0.1) in Stockholm.

Table 2 Transfers from the scene of trauma to a tertiary-level hospital (excluding those cases that were injured outside the respective country under study)

Neurological status

Approximately 30% of TSCI cases in each region had a high cervical neurological lesion (C1–C4), 10% had a low cervical lesion (C5–C8), 40% a thoracic lesion (T1–T12) and 10% a lumbosacral lesion (Figure 1). About 5% could not be confidently classified because of insufficient data. Neurologically complete lesions (ASIA Impairment Scale (AIS) A) occurred in 29 cases (36%) in Thessaloniki and in 17 cases (36%) in Stockholm. Neurologically incomplete lesions occurred in 46 cases (57%) in Thessaloniki (B: 4%, C: 21%, D: 32%) and in 26 cases (55%) in Stockholm (B: 6%, C: 19%, D: 30%). Data on AIS were unobtainable in six cases in Thessaloniki and in four cases in Stockholm because of various factors, such as the presence of extra-spinal injuries, late case identification and communication problems. When assessing completeness in relation to the aetiology of injury, falls in both regions accounted for proportionally more incomplete than complete injuries, compared with transportation-related injuries (Figure 2).

Figure 1
figure1

Neurological category distribution in the study groups.

Figure 2
figure2

Aetiology of injury in relation to completeness of lesion.

Overall, no statistically significant differences between study groups were found with regard to distribution of neurological levels, completeness of lesions, means of ASIA Total Motor Score or AIS grading. Moreover, there was no statistically significant difference when assessing the completeness of neurological lesions in relation to the neurological category (Figure 3).

Figure 3
figure3

Completeness of lesion in relation to neurological category in the study groups.

Other core clinical characteristics

For 58 cases (72%) in Thessaloniki and 30 cases (64%) in Stockholm, LOC was normal on first hospital admission according to the medical records (Table 3). Almost half of the cases in both study groups had sustained extra-spinal injuries, classified as ‘serious’ in 15 cases (19%) in Thessaloniki and in 8 (17%) in Stockholm, and as ‘life-threatening’ in 10 cases (12%) in Thessaloniki and in 4 cases (9%) in Stockholm.

Table 3 Core clinical characteristics

In summary, neither LOC on first hospital admission, nor the presence and severity of extra-spinal injuries, nor the presence of pre-morbid non-spinal disorders were significantly different between study groups. However, comorbid degenerative spinal disease was more common in the Thessaloniki group (P=0.005).

Acute key therapeutic interventions

Nearly half (49%) of the cases in Thessaloniki were put on mechanical ventilation; 28 acutely and 12 post-acutely, in contrast to Stockholm where only 20% were treated with ventilators; 9 acutely and 1 post-acutely (Table 4). Out of those who were put on mechanical ventilation, as many as 7 out of 10 in both regions also underwent a tracheostomy. Tracheostomy was performed in 29 cases (36%) in Thessaloniki; early tracheostomy in 14, late tracheostomy in 14, and unknown in 1, and in 7 cases (15%) in Stockholm; early tracheostomy in 4 and late tracheostomy in 3. Thus, there were statistically significant differences between the two regions in both of these treatment modalities, (P=0.002) and (P=0.011), respectively.

Table 4 Acute key therapeutic interventions

Spinal surgery was performed in a significantly higher proportion of cases (P=0.002) and at an earlier time point after trauma (P=0.025) in Stockholm than in Thessaloniki. Overall, in Thessaloniki, 63 out of 81 cases (78%) were operated on after an average of 10 days (median=4, s.d.=±25), whereas in Stockholm 46 out of 47 (98%) were operated on after an average of 3 days (median=1, s.d.=±4).

There were no significant differences between study groups with regard to performance of second spinal surgery, administration of anticoagulant prophylaxis and corticosteroid treatment.

Discussion

This paper evaluates the core clinical characteristics and acute management of all consecutive TSCI cases in Thessaloniki and Stockholm during the study period. To our knowledge, this is the first population-based study evaluating inception cohorts with acute TSCI in Greece and in Sweden. Undoubtedly, the two regions appear with different approaches of care for managing acute TSCI; Stockholm follows a SCI system approach with a centralized and predefined clinical process that includes an SIU, whereas Thessaloniki appears with a generic ‘non-system’ approach scattered over dozens of wards. With the exception of Thessaloniki being more rural than Stockholm and the difference in the dominant aetiology of injury, but otherwise in the absence of any other major differences between study groups in demographic8 and core clinical characteristics, the differences in treatment warrant further elucidation as to their causes.

In acute TSCI, early invasive respiratory interventions (that is, mechanical ventilation and tracheostomy) are performed either as a preventative measure or as treatment of early respiratory failure (in high cervical lesions and/or in multi-trauma patients with serious or life-threatening extra-spinal injuries), whereas late invasive respiratory interventions typically are warranted by the occurrence of severe complications.10 In this study, statistically significantly more cases in Thessaloniki underwent invasive respiratory treatment compared with cases in Stockholm.

With regard to the timing of spinal surgery, our data show a later timing in the Thessaloniki group compared with the Stockholm group. In a prospective analysis, Papadopoulos et al.11 concluded that immediate spinal surgery after acute SCI may significantly improve neurological outcome. In contrast, another prospective study12 found no statistical difference in neurological recovery between early (<72 h post trauma) and late (>5 days after trauma) spinal surgery groups. McKinley et al.13 agreed with the findings of the latter study, but also highlighted the increased length of stay, the increased costs and the higher incidence of pulmonary complications in late surgical interventions. Finally, Fehlings and Perrin14 concluded that there are currently no standards regarding the role and timing of decompression in acute SCI. Nevertheless, it has recently been recommended that surgical decompression and stabilization should be performed early after acute TSCI.3, 14

The design of this study does not allow for a detailed analysis of why type and timing of treatment differs to such a great degree. Nevertheless, we postulate that the differences reflect adaptations to the varying regional conditions of care and not the differing levels of medical skills and equipment.

In Thessaloniki, all cases were transported by road—the three extant helicopters of the National Centre of Emergency Care operate mainly in the islands.15 Furthermore, Greek cases had significantly more intermediate admissions and were in transfer for a longer time compared with the Swedish cases. In the absence of an SCI system of care in Thessaloniki, and in the most likely presence of haemodynamic and/or spinal instability, deviations in management from established clinical guidelines are probably to some extent adaptive and unavoidable. The frequent invasive respiratory interventions might thus reflect the need for assuring adequate oxygenation during long-distance transportations, whereas the time-consuming process from the trauma scene to arrival at a tertiary-level hospital may also have contributed to delayed, and perhaps in some instances deterred, spinal surgery.

Updating triage protocols for cases with suspected or diagnosed TSCI, and establishing a comprehensive system of care for acute TSCI in Greece, including regional SIUs, are likely to optimize the chain of events after injury. Establishment of regional SIUs will not only raise awareness of TSCI, but may also coordinate acute management. As suggested by Vitaz et al.,16 despite the high importance of early surgery, early mobilization and early tracheostomy in the treatment of TSCI, the total coordination of patient care as such is among the most important aspects. In conclusion, they stressed that the implementation of a clinical pathway for SCI is not only cost-effective but also ensures better quality of care leading to improved outcomes. Special thought should probably be given to rural settings, where each local catchment area has to develop its own routines on the basis of available resources, as they appear different from urban settings.17

In summary, we found statistically significant differences in acute management of TSCI between Stockholm and Thessaloniki. These differences are not explicable in terms of differences in patient characteristics, but rather reflect adaptations to different approaches of care. Subsequent outcome analysis will elucidate the impact of such differences.

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Acknowledgements

We thank the Spinalis Foundation for providing financial support to STATSCIS, making it all possible to be conducted. We would also like to thank Sara Runesdotter for assistance in statistics, Ninni Westgren and Tomas Brofelth for the constant close cooperation, and all the collaborators from both regions. The collaborators are GPG Papanikolaou Hospital; Bitzani, Lavrentieva (ICU); Kapravelos, Abatzidou (ICU); Mparoutas, Skoullios (Neurosurgical); Pournaras, Christodoulou (Orthopaedic); Christaki (Respiratory). Ahepa Univ. Hospital; Sofianos, Giala (ICU); Skourtis, Setzis, Ourailoglou (ICU); Harlaftis, Papaavramidis (ICU); Selviaridis, Ioannou, Stavrinou (Neurosurgical). G.P.G. Papageorgiou Hospital; Matamis, Sinnefaki (ICU); Kampelis, Alexiadou (Neurosurgical); Kapetanos, Likomitros (Orthopaedic); Kyriakidis, Moschoglou, Valanos (Orthopaedic); Ippokrateio Hospital; Gerogianni, Efthimiou, Papageorgiou (ICU); Mpallas (ICU); Tsitsopoulos, Tsonidis, Tsitouras (Neurosurgical); Dimitriou, Boursinos (Orthopaedic); the National Centre for Emergency Care; Mpoutlis, Matsikoudi. Karolinska Univ. Hospital; Hedman, Brofelth (SIU); Westgren, Hultling, Eriksson, Werhagen (Spinalis Clinic); Rehab Station Stockholm; Bjelak, Holmström, Lindgren; Stockholms Sjukhem; Kärvestedt, Aly, Westerlund and the Nordic Spinal Cord Injury Council.

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Correspondence to A Divanoglou.

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Divanoglou, A., Seiger, Å. & Levi, R. Acute management of traumatic spinal cord injury in a Greek and a Swedish region: a prospective, population-based study. Spinal Cord 48, 477–482 (2010). https://doi.org/10.1038/sc.2009.160

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Keywords

  • clinical characteristics
  • epidemiology
  • respiratory therapy
  • spinal injury unit
  • SCI system of care

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