Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2

Abstract

In order to determine the impact of extremely large doses of methylpredniso-lone, naloxone, or of spinal cord injury itself, on liver enzymes, we examined the results of SGOT, SGPT, alkaline phosphatase and total bilirubin tests obtained 24 hours, 3 and 10 days after the end of the study drug infusions in spinal cord injured patients entered in the National Acute Spinal Cord Injury Study.1 The mean values of four liver enzymes, the amount of change between 24 hours and 3 and 10 days post infusion, and the proportion of liver enzyme levels considered to be abnormal did not appear to be affected by either drug protocol. Even when controlling for drug protocol and severity of injury (complete vs incomplete), variation in enzyme levels appeared to be the result of the spinal cord injury, not study drugs. Spinal cord injury is routinely treated with the NASCIS dose of methylprednisolone in many countries. It is reassuring to find no evidence of compromised liver function from this steroid protocol.

References

  1. 1

    Bracken M B, Shepard M J, Collins W F et al (1990) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. Results of the second National Acute Spinal Cord Injury Study, 1990. N Engl J Med 322: 1405–1411.

    CAS  Article  Google Scholar 

  2. 2

    Bracken M B, Shepard M J, Collins W F et al (1992) Methylprednisolone or naloxone treatment after acute spinal cord injury: I-year follow-up data. Results of the second National Acute Spinal Cord Injury Study, 1992. J Neurosurg 76: 23–31.

    CAS  Article  Google Scholar 

  3. 3

    Bloom K K, Freed M M (1987) Liver enzyme abnormalities in spinal cord injury. J Am Paraplegia Soc 12: 11–13.

    Article  Google Scholar 

  4. 4

    Statistical Analysis System Institute (1982) Supplemental Users Guide SAS Institute, Cary, NC

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shepard, M., Bracken, M. The effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2. Spinal Cord 32, 236–245 (1994). https://doi.org/10.1038/sc.1994.43

Download citation

Keywords

  • spinal cord trauma
  • methylprednisolone
  • naloxone
  • liver enzymes
  • NASCIS 2

Search

Quick links