Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Spinal Cord
  • View all journals
  • Search
  • Log in
  • Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • RSS feed
  1. nature
  2. spinal cord
  3. articles
  4. article
Anterior spinal artery syndrome and its natural history
Download PDF
Your article has downloaded

Similar articles being viewed by others

Slider with three articles shown per slide. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide.

Cervical spinal cord infarction due to impingement of an anomalous right vertebral artery by thoracic osteophyte

28 October 2021

Abhinav Mohan, Hanna Mielke-Maday & Joanne Delgado-Lebron

Cervical arterial dissection and traumatic myelopathy following yoga: surgical case report

27 April 2022

Gautam Nayar, Ansh Desai, … John J. Moossy

An arterial insufficiency ulcer in an individual with cervical spinal cord injury and hypotension

18 May 2020

Michael Stillman & Steve Williams

Multilevel critical stenosis with minimal functional deficits: a case of cervical spondylotic myelopathy

19 November 2018

Anup K. Gangavalli, Ajith Malige & Gbolabo Sokunbi

Pediatric spinal cord infarction following a minor trauma: a case report

12 October 2020

Ali Morshid, Huda Al Jadiry, … Karthikram Raghuram

Neuropathic spinal arthropathy leading to spine disruption, spinal cord transection, and aortic displacement: brief case report

11 October 2018

Lance L. Goetz, Sean McAvoy & Kate Zakrzewski

Neurological presentation of acute aortic syndrome: Type A intramural haematoma presenting as ischaemic hemisection of the spinal cord

06 July 2020

Christopher Seet, James Walker, … Rachel Bell

Fibrocartilagenous embolism case series: is it a zebra?

13 April 2021

Christina Draganich & Lisa R. Wenzel

Surgical resection of arteriovenous fistula at the cauda equina

13 April 2021

Toshiyuki Shimizu, Narihito Nagoshi, … Morio Matsumoto

Download PDF
  • Published: 01 February 1983

Anterior spinal artery syndrome and its natural history

  • Dominic Foo1,2,3 &
  • Alain B Rossier1,4 

Spinal Cord volume 21, pages 1–10 (1983)Cite this article

  • 3912 Accesses

  • 82 Citations

  • 3 Altmetric

  • Metrics details

Abstract

The anterior spinal artery syndrome in three patients is described and from the literature 6o additional patients were collected. Motor recovery in the following groups of patients was noted: (1) Partial loss of motor function and pain sensation—70.4 per cent (19/27); (2) Complete motor loss but partial loss of pain—83.3 per cent (5/6); (3) Paresis but pain sensation absent—66.7 per cent (6/9); and (4) Absent motor function and pain—38.9 per cent (7/18). Motor recovery was also found to vary according to aetiology: (A) Unknown cause— 92.9 per cent (13/14); (B) Post-infection or vaccination—88.9 per cent (8/9); (C) Anterior spinal artery occlusion—33.3 per cent (3/9); (D) Spinal cord angioma—20 per cent (2/10); and (E) Aortic lesion—2o per cent (1/5).

Patients with sparing of motor function or pain sensation below the lesion do better than those without both functions. Neurological return also varies with the aetiology of the syndrome.

References

  1. Albert, M L, Greer, W E R, Kantrowitz, W (1969). Paraplegia secondary to hypotension and cardiac arrest in a patient who has had previous thoracic surgery. Neurology (Ny), 19, 915–918.

    Article  CAS  Google Scholar 

  2. Blankenhorn, D, Wolff, H G (1948). Myelitis following the administration of neoarsphenamine. J. Lab. Clin. Med., 33, 1165–1168.

    CAS  PubMed  Google Scholar 

  3. Case Records (Case 38012) of the Massachusetts General Hospital (1952). Anterior spinal artery thrombosis. New Engl. J. Med., 246, 30–34.

  4. Clinicopathologic Conference (1968). A sixty-six year old man with the sudden onset of left-sided chest and arm pain, weakness of the extremities and urinary retention. Am. J. Med., 44, 430–440.

  5. Coupland, G A E, Reeve, T S (1968). Paraplegia: a complication of excision of abdominal aortic aneurysm. Surgery, 64, 878–881.

    CAS  PubMed  Google Scholar 

  6. Deller, J J Jr, Scalettar, R, Levens, A J (1960). Pain as a manifestation of acute anterior-spinal-artery thrombosis. New Engl. J. Med., 262, 1078–1079.

    Article  Google Scholar 

  7. Fiebrand, H (1966). Zur Pathogenese des Spinalis-anterior-Syndroms. Schweiz. Arch. Neurol. Neurochir. und Psychiat., 97, 227–233.

    CAS  Google Scholar 

  8. Foo, D, Subrahmanyan, T S, Rossier, A B (1981). Post-traumatic acute anterior spinal cord syndrome. Paraplegia, 19, 201–205.

    CAS  PubMed  Google Scholar 

  9. Foo, D, Bignami, A, Rossier, A B (1982). Post-traumatic anterior spinal cord syndrome: pathological studies of two patients. Surg. Neurol., 17, 370–375.

    Article  CAS  Google Scholar 

  10. Garland, H, Greenberg, J, Harriman, D G F (1966). Infarction of the spinal cord. Brain, 89, 645–662.

    Article  CAS  Google Scholar 

  11. Grinker, R R, Guy, C C (1927). Sprain of cervical spine causing thrombosis of anterior spinal artery. J. A. M. A., 88, 1140–1142.

    Article  Google Scholar 

  12. Henneaux, J (1960). Étude clinique et anatomo-pathologique de deux cas de thrombose de l’artère spinale antérieure. Rev. Neurol., 102, 44–60.

    CAS  PubMed  Google Scholar 

  13. Hogan, B W (1942). Acute myelitis: syndrome of occlusion of the anterior spinal artery at the first thoracic cord segment with softening of the cord. U. S. Navy Med. Bull., 40, 175–178.

    Google Scholar 

  14. Hogan, E L, Romanul, F C A (1996.). Spinal cord infarction occurring during insertion of aortic graft. Neurology (Ny), 16, 67–74.

    Article  Google Scholar 

  15. Hughes, J T (1978). Pathology of the Spinal Cord, 2nd ed. Lloyd-Luke, London.

  16. Hughes, J T, Brownell, B (1964). Cervical spondylosis complicated by anterior spinal artery thrombosis. Neurology (Ny), 14, 1073–1077.

    Article  CAS  Google Scholar 

  17. Killen, D A, Foster, J H (1966). Spinal cord injury as a complication of contrast angiography. Surgery, 59, 969–981.

    CAS  Google Scholar 

  18. Lyon, L W (1971). Transfemoral vertebral angiography as a cause of anterior spinal artery syndrome: case report. J. Neurosurg., 35, 328–330.

    Article  CAS  Google Scholar 

  19. Mosberg, W H JR, Voris, H C, Duffy, J (1954). Paraplegia as a complication of sympathectomy for hypertension. Ann. Surg., 139, 330–334.

    Article  Google Scholar 

  20. Mulder, D G, Grollman, J H (1969). Traumatic disruption of the thoracic aorta: diagnostic and surgical considerations. Am. J. Surg., 118, 311–316.

    Article  CAS  Google Scholar 

  21. Paine, R S, Byers, R K (1953). Transverse myelopathy in childhood. Am. J. Dis. Child., 85, 151–163.

    CAS  Google Scholar 

  22. Parman, S C (1980). Spontaneous spinal epidural hematoma: case report. Ann. Emerg. Med., 9, 368–370.

    Article  CAS  Google Scholar 

  23. Parmley, L F, Mattingly, T W, Manion, W C, Jahnke, E J JR (1958). Non-penetrating traumatic injury of the aorta. Circulation, 17, 1086–1101.

    Article  CAS  Google Scholar 

  24. Peterman, A F, Yoss, R E, Corbin, K B (1958). The syndrome of occlusion of the anterior spinal artery. Proc. Mayo Clinic, 33, 31–37.

    CAS  Google Scholar 

  25. Schaller, W F, Roberts, A M, Stadtherr, E F (1932). Acute myelitis (myelomalacia): syndrome of occlusion of the anterior spinal artery at the fifth cervical cord segment. J. A. M. A., 99, 1572–1575.

    Article  Google Scholar 

  26. Slavin, R E, Gonzalez-Vitale, J C, Marin, O S M (1975). Atheromatous emboli to the lumbosacral spinal cord. Stroke, 6, 411–416.

    Article  CAS  Google Scholar 

  27. Spiller, W G (1909). Thrombosis of the cervical anterior median spinal artery; syphilitic acute anterior poliomyelitis. J. Nerv. & Ment. Dis., 36, 601–613.

    Article  Google Scholar 

  28. Steegmann, A T (1952). Syndrome of the anterior spinal artery. Neurology (Ny), 2, 15–35.

    Article  CAS  Google Scholar 

  29. Strassman, G (1947). Traumatic rupture of the aorta. Am. Heart J., 33, 508–515.

    Article  CAS  Google Scholar 

  30. Watson, A B (1967). Spinal subarachnoid haemorrhage in patient with coarctation of aorta. Br. Med. J., 4, 278–279.

    Article  CAS  Google Scholar 

  31. Weisman, A D, Adams, R D (1944). The neurological complications of dissecting aortic aneurysm. Brain, 67, 69–92.

    Article  Google Scholar 

  32. Wieringen, A V (1968). An unusual cause of occlusion of the anterior spinal artery. Europ. Neurol., 1, 363–374.

    Article  Google Scholar 

  33. Wyburn-Mason, R (1943). Vascular Abnormalities and Tumours of Spinal Cord and Its Membranes. Henry Kimpton, London.

    Google Scholar 

  34. Zeitlin, H, Lichtenstein, B W (1936). Occlusion of the anterior spinal artery: clinicopathologic report of a case and a review of the literature. Arch. Neurol. Psychiat., 36, 96–111.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Spinal Cord Injury, U.S.A.

    Dominic Foo & Alain B Rossier

  2. Neurology Services, West Roxbury Veterans Administration Medical Center, U.S.A.

    Dominic Foo

  3. Department of Neurology, U.S.A.

    Dominic Foo

  4. Orthopaedic Surgery, Harvard Medical School, Boston, Mass, U.S.A.

    Alain B Rossier

Authors
  1. Dominic Foo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alain B Rossier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Foo, D., Rossier, A. Anterior spinal artery syndrome and its natural history. Spinal Cord 21, 1–10 (1983). https://doi.org/10.1038/sc.1983.1

Download citation

  • Issue Date: 01 February 1983

  • DOI: https://doi.org/10.1038/sc.1983.1

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • Anterior spinal artery (ASA)
  • Motor function
  • Pain sensation

This article is cited by

  • Young Woman with Sudden-Onset Neck Pain and Quadriplegia: a Case Report

    • Koshi Ota
    • Shoji Ogawa
    • Akira Takasu

    SN Comprehensive Clinical Medicine (2021)

  • Neurological symptoms in acute Leriche’s syndrome

    • Alexandra R. Zankl
    • E. Blessing
    • M. Andrassy

    Clinical Research in Cardiology (2010)

  • Anterior spinal artery syndrome complicating massive paravertebral abscess

    • Kenzo Uchida
    • Shigeru Kobayashi
    • Hisatoshi Baba

    Journal of Orthopaedic Science (2008)

  • Spinal Cord Ischemia following Endovascular Repair of an Infrarenal Aortic Aneurysm

    • Nicholas D. Garcia
    • Hassan Tehrani
    • Jon Matsumura

    Annals of Vascular Surgery (2002)

  • Anterior spinal artery syndrome of the cervical hemicord

    • Ralf W. Baumgartner
    • Walter Waespe

    European Archives of Psychiatry and Clinical Neuroscience (1992)

Download PDF

Advertisement

Explore content

  • Research articles
  • Reviews & Analysis
  • News & Comment
  • Current issue
  • Collections
  • Follow us on Facebook
  • Follow us on Twitter
  • Sign up for alerts
  • RSS feed

About the journal

  • Calendar of Events
  • Journal Information
  • Open Access Publishing
  • About the Editors
  • About the Partner
  • Contact
  • For Advertisers

Publish with us

  • For Authors & Referees
  • Language editing services
  • Submit manuscript

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

Spinal Cord (Spinal Cord) ISSN 1476-5624 (online) ISSN 1362-4393 (print)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • Nano
  • Protocol Exchange
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Nature Research Academies
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Career development

  • Nature Careers
  • Nature Conferences
  • Nature events

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Italy
  • Nature Japan
  • Nature Korea
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • California Privacy Statement
Springer Nature

© 2023 Springer Nature Limited