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Biocomputing with organoid intelligence

Organoid intelligence towards biocomputing may provide insights into the neuroscience of learning and memory, and offer a biohybrid form of information processing. Advances in brain region-specific organoid engineering, sensors and signal-processing tools, integration of artificial intelligence, and miniaturization will pave the way for organoid intelligence to make an impact in biomedicine and beyond.

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I thank T. Hartung, B. Caffo, D. Gracias, L. Boyd, B. Kagan and E. Johnson for inspiring discussions. The OI work was supported by a Johns Hopkins Discovery award and a Johns Hopkins SURPASS award.

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Correspondence to Lena Smirnova.

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Smirnova, L. Biocomputing with organoid intelligence. Nat Rev Bioeng (2024).

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