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Engineering good viruses to improve crop performance

Viruses can be engineered to deliver nucleic acids, peptides and proteins for plant trait reprogramming. Building on market approvals and sales of recombinant virus-based biopharmaceuticals for veterinary and human medicine, similar innovations may be applied to agriculture for transient or heritable biodesign of crops with improved performance and sustainable production.

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Fig. 1: Engineering viruses for crop biodesign and agriculture.


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F.P. is supported by a ‘Juan de la Cierva Incorporación’ contract (IJC2019-039970-I) from Ministerio de Ciencia e Innovación (Spain), and M.U. by the Marie Skłodowska-Curie Actions (HORIZON-MSCA-2022-PF-01-101110621) from the European Commission. F.P. gratefully acknowledges grants MiniVi (ELIXIR-IIB, Cineca, Italy) and BCV-2023-1-0021 (Red Española de Supercomputación, Spain), and resources provided by Centro de Supercomputación de Galicia (CESGA, Spain). C.-T.K. is supported by the National Research Foundation (NRF) of the Ministry of Science and ICT (MSIT), Republic of Korea (2022R1C1C1002941).

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F.P. conceived the work and drafted the manuscript; M.U., R.C. and C.-T.K. collaborated on the manuscript preparation. All authors revised and approved the final version.

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Correspondence to Fabio Pasin.

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The authors declare no competing interests.

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Pasin, F., Uranga, M., Charudattan, R. et al. Engineering good viruses to improve crop performance. Nat Rev Bioeng (2024).

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