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Modelling patient drug exposure profiles in vitro to narrow the valley of death

The current drug development pipeline is time-consuming, costly and inefficient. To better model interactions between pharmaceuticals and human physiology and, thus, increase the likelihood of drug success in clinical trials, the effect of pharmacokinetic drug profiles on cellular behaviour should be tested early in drug development.

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Fig. 1: In vitro testing of in vivo pharmacokinetic (PK) profiles.


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G.N. is supported by National Institutes of Health (NIH) R01GM140240 and Vanderbilt Basic Science Dean’s Faculty Fellow Endowed Chair.

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C.S.L. and G.N. conceived the concept for the article and C.S.L. drafted the manuscript. G.N. critically reviewed and edited the manuscript.

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Correspondence to Gregor Neuert.

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Competing interests

G.N. is a co-inventor of the pending patent WO2023220749A2. C.S.L. declares no competing interests.

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Leasure, C.S., Neuert, G. Modelling patient drug exposure profiles in vitro to narrow the valley of death. Nat Rev Bioeng 2, 196–197 (2024).

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