Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perspective
  • Published:

Lessons on targeting family mental health and improving outcomes for children of parents with a mental illness

Abstract

Children of parents with a mental illness (COPMI) are at risk of adverse outcomes, as well as of developing a mental illness themselves. Recognition of modifiable risk factors, along with targeted initiatives and interventions have the potential to improve their and their families’ strengths and resilience, and thus effectively interrupt this vicious circle of the transgenerational transmission of mental disorders. Although several international projects have been funded and implemented, their planning, implementation and translation are not free from problems and downsides, and the use of measures specifically targeting COPMI is not yet part of regular clinical practice. Here we illustrate four European projects targeting family mental health, addressing the main problems encountered and the principal focuses for future directions, as learned from live discussions between project team members, participating patients/parents and other stakeholders. Our goal was to summarize those as lessons learned and make them available to the public and research community.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mental Disorders https://www.who.int/news-room/fact-sheets/detail/mental-disorders (World Health Organization, 2022).

  2. McGrath, J. J. et al. Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries. Lancet Psychiatry 10, 668–681 (2023).

    Article  PubMed  Google Scholar 

  3. Kessler, R. C. et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593–602 (2005).

    Article  PubMed  Google Scholar 

  4. Uher, R. et al. Transdiagnostic risk of mental disorders in offspring of affected parents: a meta-analysis of family high-risk and registry studies. World Psychiatry 22, 433–448 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Leijdesdorff, S. et al. Prevalence of psychopathology in children of parents with mental illness and/or addiction: an up to date narrative review. Curr. Opin. Psychiatry 30, 312–317 (2017).

    Article  PubMed  Google Scholar 

  6. Schwenck, C., Christiansen, H. & Goetz, M. in IACAPAP e-Textbook of Child and Adolescent Mental Health (eds Rey, J. M. & Martin. A.) Ch. J.13 (International Association for Child and Adolescent Psychiatry and Allied Professions, 2020).

  7. Duffy, A. et al. The well-being of children at familial risk of severe mental illness: an overlooked yet crucial prevention and early intervention opportunity. Nat. Mental Health 1, 534–541 (2023).

    Article  Google Scholar 

  8. Hosman, C. M. H., van Doesum, K. T. M. & van Santvoort, F. Prevention of emotional problems and psychiatric risks in children of parents with a mental illness in the Netherlands: I. The scientific basis to a comprehensive approach. AeJAMH 8, 250–263 (2009).

    Google Scholar 

  9. Lannes, A. et al. Preventive interventions in offspring of parents with mental illness: a systematic review and meta-analysis of randomized controlled trials. Psychol. Med. 51, 2321–2336 (2021).

    Article  PubMed  Google Scholar 

  10. Siegenthaler, E., Munder, T. & Egger, M. Effect of preventive interventions in mentally ill parents on the mental health of the offspring: systematic review and meta-analysis. J. Am. Acad. Child Adolesc. Psychiatry 51, 8–17 (2012).

    Article  PubMed  Google Scholar 

  11. Thanhäuser, M., Lemmer, G., de Girolamo, G. & Christiansen, H. Do preventive interventions for children of mentally ill parents work? Results of a systematic review and meta-analysis. Curr. Opin. Psychiatry 30, 283–299 (2017).

    Article  PubMed  Google Scholar 

  12. Baldwin, J. R. et al. A genetically informed Registered Report on adverse childhood experiences and mental health. Nat. Hum. Behav. 7, 269–290 (2023).

    Article  PubMed  Google Scholar 

  13. Ranning, A. et al. Intergenerational transmission of suicide attempt in a cohort of 4.4 million children. Psychol. Med. 52, 3202–3209 (2022).

    Article  PubMed  Google Scholar 

  14. Arango, C. et al. Preventive strategies for mental health. Lancet Psychiatry 5, 591–604 (2018).

    Article  PubMed  Google Scholar 

  15. Goodyear, M. et al. Development of an evidence-informed and codesigned model of support for children of parents with a mental illness- ‘it takes a village’ approach. Front. Psychiatry 12, 806884 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  16. Rosenbach, C. et al. Study protocol for a multi-center RCT testing a group-based parenting intervention tailored to mothers with borderline personality disorder against a waiting control group (ProChild*-SP1). Trials 23, 589 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  17. Christiansen, H. et al. Improving identification and child-focused collaborative care for children of parents with a mental illness in Tyrol, Austria. Front. Psychiatry 10, 233 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  18. Müller, A. D. et al. VIA Family—a family-based early intervention versus treatment as usual for familial high-risk children: a study protocol for a randomized clinical trial. Trials 20, 112 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  19. Nicholson, J., Paul, J. L., Riebschleger, J. & Wittkowski, A. Editorial: Parents with mental and/or substance use disorders and their children, volume II. Front. Psychiatry 13, 1020660 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  20. Reupert, A. et al. Editorial perspective: Prato Research Collaborative for change in parent and child mental health – principles and recommendations for working with children and parents living with parental mental illness. J. Child. Psychol. Psychiatr. 63, 350–353 (2022).

    Article  Google Scholar 

  21. Stracke, M. et al. COMPARE Family (Children of Mentally Ill Parents at Risk Evaluation): a study protocol for a preventive intervention for children of mentally ill parents (Triple P, Evidence-Based Program That Enhances Parentings Skills, in Addition to Gold-Standard CBT With the Mentally Ill Parent) in a Multicenter RCT-Part II. Front. Psychiatry 10, 54 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  22. Heinrichs, N., Kliem, S. & Hahlweg, K. Four-year follow-up of a randomized controlled trial of Triple P group for parent and child outcomes. Prev. Sci. 15, 233–245 (2014).

    Article  PubMed  Google Scholar 

  23. Sanders, M. R., Kirby, J. N., Tellegen, C. L. & Day, J. J. The Triple P-Positive Parenting Program: a systematic review and meta-analysis of a multi-level system of parenting support. Clin. Psychol. Rev. 34, 337–357 (2014).

    Article  PubMed  Google Scholar 

  24. Wilson, P. et al. How evidence-based is an ‘evidence-based parenting program’? A PRISMA systematic review and meta-analysis of Triple P. BMC Med. 10, 130 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  25. Christiansen, H. et al. Children of Mentally III Parents at Risk Evaluation (COMPARE): design and methods of a Randomized Controlled Multicenter Study-Part I. Front. Psychiatry 10, 128 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  26. Muller, A. D. et al. Family-based preventive intervention for children of parents with severe mental illness: a randomized clinical trial. ICPP Adv. 2024, e12216 (2024).

    Google Scholar 

  27. Thorup, A. A. E. et al. The Danish High Risk and Resilience Study—VIA 7—a cohort study of 520 7-year-old children born of parents diagnosed with either schizophrenia, bipolar disorder or neither of these two mental disorders. BMC Psychiatry 15, 233 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  28. Zechmeister-Koss, I. et al. Practices to support co-design processes: a case-study of co-designing a program for children with parents with a mental health problem in the Austrian region of Tyrol. Int. J. Mental Health Nurs. 32, 223–235 (2023).

    Article  Google Scholar 

  29. Bauer, A. et al. Acceptability, engagement and exploratory outcomes and costs of a co-designed intervention to support children of parents with a mental illness: mixed-methods evaluation and descriptive analysis. Int. J. Ment. Health Nurs. https://doi.org/10.1111/inm.13324 (2024).

    Article  PubMed  Google Scholar 

  30. Goodyear, M. et al. The ‘It Takes a Village’ Practice Manual (Monash Univ., 2023); https://doi.org/10.26180/22564960.v3

  31. Rosenbach, C., Buck-Horstkotte, S. & Renneberg, B. Parenting Skills for Mothers with Borderline Personality Disorder—a group training (Freie Universität Berlin, 2020).

  32. Rose, G. Strategy of prevention: lessons from cardiovascular disease. Brit. Med. J. 282, 1847–1851 (1981).

    Article  Google Scholar 

  33. Rossow, I. & Romelsjö, A. The extent of the ‘prevention paradox’ in alcohol problems as a function of population drinking patterns. Addiction 101, 84–90 (2006).

    Article  PubMed  Google Scholar 

  34. Engelke, L. et al. Parental mental health and child maltreatment in the COVID-19 pandemic: the representativeness of the sample matters. Preprint at https://preprints.jmir.org/preprint/52043 (2023).

  35. Meyer-Lindenberg, A. et al. The future German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit): a model for the co-creation of a national translational research structure. Nat. Mental Health 1, 153–156 (2023).

    Article  Google Scholar 

  36. Huhta, H. et al. Expanding the understanding of low-threshold services for young people. Perspectives into topical issues in society and ways to support political decision making. Policy Brief 2023:9 (Finnish Government, Prime Minister’s Office, 2023).

  37. Dobener, L. M. et al. How do children of parents with mental illness experience stigma? A systematic mixed studies review. Front. Psychiatry 13, 813519 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  38. Dobener, L. M. et al. Children of parents with a mental illness-stigma questionnaire: development and piloting. Front. Psychiatry 13, 800037 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  39. Stracke, M., Dobener, L.-M. & Christiansen, H. Children of parents with a mental illness-stigma questionnaire: validation and revision. Front. Psychiatry 15, 1376627 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  40. Hinshaw, S. P. & Cicchetti, D. Stigma and mental disorder: conceptions of illness, public attitudes, personal disclosure and social policy. Dev. Psychopathol. 12, 555–598 (2000).

    Article  PubMed  Google Scholar 

  41. Yalom, I. D. & Leszcz, M. The Theory and Practice of Group Psychotherapy 5th edn (Basic Books/Hachette Book Group, 2005).

  42. Zechmeister-Koss, I. et al. Economic evaluation of family-focused programs when parents have a mental health problem: methodological considerations. Value Health 26, 704–711 (2023).

    Article  PubMed  Google Scholar 

  43. Children displaced in a changing climate (UNICEF, 2023); https://www.unicef.org/media/145951/file/Climate%20displacement%20report%20 (English).pdf

  44. Totzeck, C. et al. Systematic review: patient and public involvement of children and young people in mental health research. Clin. Child. Fam. Psychol. Rev. 27, 257–274 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  45. Borntrager, C. & Lyon, A. R. Monitoring client progress and feedback in school-based mental health. Cogn. Behav. Pract. 22, 74–86 (2015).

    Article  PubMed  Google Scholar 

  46. Brookman-Frazee, L. et al. Using survival analysis to understand patterns of sustainment within a system-driven implementation of multiple evidence-based practices for children’s mental health services. Front. Public Health 6, 54 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  47. Chorpita, B. F. et al. Long term outcomes for the child steps randomized effectiveness trial: a comparison of modular and standard treatment designs with usual care. J. Consult. Clin. Psychol. 81, 999–1009 (2013).

    Article  PubMed  Google Scholar 

  48. Cheron, D. M. et al. Assessing practical implementation of modular psychotherapy for youth in community-based settings using benchmarking. Implement. Res. Pract. 3, 26334895221115216 (2022).

    PubMed  PubMed Central  Google Scholar 

  49. Jørgensen, K., Hansen, M. & Karlsson, B. Recovery-oriented practices in a mental health centre for citizens experiencing serious mental issues and substance use: as perceived by healthcare professionals. Int. J. Environ. Res. Public Health 19, 10294 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  50. Jørgensen, K. et al. Recovery-oriented intersectoral care in mental health: as perceived by healthcare professionals and users. Int. J. Environ. Res. Public Health 17, 8777 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  51. Jørgensen, K. et al. Perspectives on recovery-oriented care in mental health practices: health professionals experiences. Issues Ment. Health Nurs. 44, 200–208 (2023).

    Article  PubMed  Google Scholar 

  52. Dziobek, I. et al. Die beteiligung von Betroffenen und Angehörigen am Deutschen Zentrum für Psychische Gesundheit. Nervenarzt. 93, 300–301 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  53. Lipinski, S. et al. Patient and public involvement am Deutschen Zentrum für Psychische Gesundheit: Erreichtes und Herausforderungen. Nervenarzt 95, 458–466 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  54. Zechmeister-Koss, I. et al. Reaching families where a parent has a mental disorder: using big data to plan early interventions. Neuropsychiatr. 34, 39–47 (2020).

    Article  PubMed  Google Scholar 

  55. West, S. G. et al. Propensity scores as a basis for equating groups: basic principles and application in clinical treatment outcome research. J. Consult. Clin. Psychol. 82, 906–919 (2014).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We wish to thank all families who participated in the projects. The study was funded by the German Federal Ministry of Education and Research (funding # 01GL1748B).

Author information

Authors and Affiliations

Authors

Contributions

E.T., M.S. and H.C. contributed to the conception of the work and wrote the initial draft of the manuscript. S.F., G.d.G., K.G., C.R., K.O., R.S., B.R., J.L.P. and A.A.E.T. critically reviewed the manuscript for intellectual content. All authors reviewed and edited subsequent drafts, and approved the final version.

Corresponding author

Correspondence to Elena Toffol.

Ethics declarations

Competing interests

The authors declare no competing interests.

Peer review

Peer review information

Nature Mental Health thanks Katharina Kircanski and the other, anonymous, reviewers for their contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Supplementary Information

Supplementary Fig. 1.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Toffol, E., Stracke, M., Harlos, N. et al. Lessons on targeting family mental health and improving outcomes for children of parents with a mental illness. Nat. Mental Health 2, 893–900 (2024). https://doi.org/10.1038/s44220-024-00285-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44220-024-00285-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing