Abstract
Children of parents with a mental illness (COPMI) are at risk of adverse outcomes, as well as of developing a mental illness themselves. Recognition of modifiable risk factors, along with targeted initiatives and interventions have the potential to improve their and their families’ strengths and resilience, and thus effectively interrupt this vicious circle of the transgenerational transmission of mental disorders. Although several international projects have been funded and implemented, their planning, implementation and translation are not free from problems and downsides, and the use of measures specifically targeting COPMI is not yet part of regular clinical practice. Here we illustrate four European projects targeting family mental health, addressing the main problems encountered and the principal focuses for future directions, as learned from live discussions between project team members, participating patients/parents and other stakeholders. Our goal was to summarize those as lessons learned and make them available to the public and research community.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$79.00 per year
only $6.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mental Disorders https://www.who.int/news-room/fact-sheets/detail/mental-disorders (World Health Organization, 2022).
McGrath, J. J. et al. Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries. Lancet Psychiatry 10, 668–681 (2023).
Kessler, R. C. et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593–602 (2005).
Uher, R. et al. Transdiagnostic risk of mental disorders in offspring of affected parents: a meta-analysis of family high-risk and registry studies. World Psychiatry 22, 433–448 (2023).
Leijdesdorff, S. et al. Prevalence of psychopathology in children of parents with mental illness and/or addiction: an up to date narrative review. Curr. Opin. Psychiatry 30, 312–317 (2017).
Schwenck, C., Christiansen, H. & Goetz, M. in IACAPAP e-Textbook of Child and Adolescent Mental Health (eds Rey, J. M. & Martin. A.) Ch. J.13 (International Association for Child and Adolescent Psychiatry and Allied Professions, 2020).
Duffy, A. et al. The well-being of children at familial risk of severe mental illness: an overlooked yet crucial prevention and early intervention opportunity. Nat. Mental Health 1, 534–541 (2023).
Hosman, C. M. H., van Doesum, K. T. M. & van Santvoort, F. Prevention of emotional problems and psychiatric risks in children of parents with a mental illness in the Netherlands: I. The scientific basis to a comprehensive approach. AeJAMH 8, 250–263 (2009).
Lannes, A. et al. Preventive interventions in offspring of parents with mental illness: a systematic review and meta-analysis of randomized controlled trials. Psychol. Med. 51, 2321–2336 (2021).
Siegenthaler, E., Munder, T. & Egger, M. Effect of preventive interventions in mentally ill parents on the mental health of the offspring: systematic review and meta-analysis. J. Am. Acad. Child Adolesc. Psychiatry 51, 8–17 (2012).
Thanhäuser, M., Lemmer, G., de Girolamo, G. & Christiansen, H. Do preventive interventions for children of mentally ill parents work? Results of a systematic review and meta-analysis. Curr. Opin. Psychiatry 30, 283–299 (2017).
Baldwin, J. R. et al. A genetically informed Registered Report on adverse childhood experiences and mental health. Nat. Hum. Behav. 7, 269–290 (2023).
Ranning, A. et al. Intergenerational transmission of suicide attempt in a cohort of 4.4 million children. Psychol. Med. 52, 3202–3209 (2022).
Arango, C. et al. Preventive strategies for mental health. Lancet Psychiatry 5, 591–604 (2018).
Goodyear, M. et al. Development of an evidence-informed and codesigned model of support for children of parents with a mental illness- ‘it takes a village’ approach. Front. Psychiatry 12, 806884 (2022).
Rosenbach, C. et al. Study protocol for a multi-center RCT testing a group-based parenting intervention tailored to mothers with borderline personality disorder against a waiting control group (ProChild*-SP1). Trials 23, 589 (2022).
Christiansen, H. et al. Improving identification and child-focused collaborative care for children of parents with a mental illness in Tyrol, Austria. Front. Psychiatry 10, 233 (2019).
Müller, A. D. et al. VIA Family—a family-based early intervention versus treatment as usual for familial high-risk children: a study protocol for a randomized clinical trial. Trials 20, 112 (2019).
Nicholson, J., Paul, J. L., Riebschleger, J. & Wittkowski, A. Editorial: Parents with mental and/or substance use disorders and their children, volume II. Front. Psychiatry 13, 1020660 (2022).
Reupert, A. et al. Editorial perspective: Prato Research Collaborative for change in parent and child mental health – principles and recommendations for working with children and parents living with parental mental illness. J. Child. Psychol. Psychiatr. 63, 350–353 (2022).
Stracke, M. et al. COMPARE Family (Children of Mentally Ill Parents at Risk Evaluation): a study protocol for a preventive intervention for children of mentally ill parents (Triple P, Evidence-Based Program That Enhances Parentings Skills, in Addition to Gold-Standard CBT With the Mentally Ill Parent) in a Multicenter RCT-Part II. Front. Psychiatry 10, 54 (2019).
Heinrichs, N., Kliem, S. & Hahlweg, K. Four-year follow-up of a randomized controlled trial of Triple P group for parent and child outcomes. Prev. Sci. 15, 233–245 (2014).
Sanders, M. R., Kirby, J. N., Tellegen, C. L. & Day, J. J. The Triple P-Positive Parenting Program: a systematic review and meta-analysis of a multi-level system of parenting support. Clin. Psychol. Rev. 34, 337–357 (2014).
Wilson, P. et al. How evidence-based is an ‘evidence-based parenting program’? A PRISMA systematic review and meta-analysis of Triple P. BMC Med. 10, 130 (2012).
Christiansen, H. et al. Children of Mentally III Parents at Risk Evaluation (COMPARE): design and methods of a Randomized Controlled Multicenter Study-Part I. Front. Psychiatry 10, 128 (2019).
Muller, A. D. et al. Family-based preventive intervention for children of parents with severe mental illness: a randomized clinical trial. ICPP Adv. 2024, e12216 (2024).
Thorup, A. A. E. et al. The Danish High Risk and Resilience Study—VIA 7—a cohort study of 520 7-year-old children born of parents diagnosed with either schizophrenia, bipolar disorder or neither of these two mental disorders. BMC Psychiatry 15, 233 (2015).
Zechmeister-Koss, I. et al. Practices to support co-design processes: a case-study of co-designing a program for children with parents with a mental health problem in the Austrian region of Tyrol. Int. J. Mental Health Nurs. 32, 223–235 (2023).
Bauer, A. et al. Acceptability, engagement and exploratory outcomes and costs of a co-designed intervention to support children of parents with a mental illness: mixed-methods evaluation and descriptive analysis. Int. J. Ment. Health Nurs. https://doi.org/10.1111/inm.13324 (2024).
Goodyear, M. et al. The ‘It Takes a Village’ Practice Manual (Monash Univ., 2023); https://doi.org/10.26180/22564960.v3
Rosenbach, C., Buck-Horstkotte, S. & Renneberg, B. Parenting Skills for Mothers with Borderline Personality Disorder—a group training (Freie Universität Berlin, 2020).
Rose, G. Strategy of prevention: lessons from cardiovascular disease. Brit. Med. J. 282, 1847–1851 (1981).
Rossow, I. & Romelsjö, A. The extent of the ‘prevention paradox’ in alcohol problems as a function of population drinking patterns. Addiction 101, 84–90 (2006).
Engelke, L. et al. Parental mental health and child maltreatment in the COVID-19 pandemic: the representativeness of the sample matters. Preprint at https://preprints.jmir.org/preprint/52043 (2023).
Meyer-Lindenberg, A. et al. The future German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit): a model for the co-creation of a national translational research structure. Nat. Mental Health 1, 153–156 (2023).
Huhta, H. et al. Expanding the understanding of low-threshold services for young people. Perspectives into topical issues in society and ways to support political decision making. Policy Brief 2023:9 (Finnish Government, Prime Minister’s Office, 2023).
Dobener, L. M. et al. How do children of parents with mental illness experience stigma? A systematic mixed studies review. Front. Psychiatry 13, 813519 (2022).
Dobener, L. M. et al. Children of parents with a mental illness-stigma questionnaire: development and piloting. Front. Psychiatry 13, 800037 (2022).
Stracke, M., Dobener, L.-M. & Christiansen, H. Children of parents with a mental illness-stigma questionnaire: validation and revision. Front. Psychiatry 15, 1376627 (2024).
Hinshaw, S. P. & Cicchetti, D. Stigma and mental disorder: conceptions of illness, public attitudes, personal disclosure and social policy. Dev. Psychopathol. 12, 555–598 (2000).
Yalom, I. D. & Leszcz, M. The Theory and Practice of Group Psychotherapy 5th edn (Basic Books/Hachette Book Group, 2005).
Zechmeister-Koss, I. et al. Economic evaluation of family-focused programs when parents have a mental health problem: methodological considerations. Value Health 26, 704–711 (2023).
Children displaced in a changing climate (UNICEF, 2023); https://www.unicef.org/media/145951/file/Climate%20displacement%20report%20 (English).pdf
Totzeck, C. et al. Systematic review: patient and public involvement of children and young people in mental health research. Clin. Child. Fam. Psychol. Rev. 27, 257–274 (2024).
Borntrager, C. & Lyon, A. R. Monitoring client progress and feedback in school-based mental health. Cogn. Behav. Pract. 22, 74–86 (2015).
Brookman-Frazee, L. et al. Using survival analysis to understand patterns of sustainment within a system-driven implementation of multiple evidence-based practices for children’s mental health services. Front. Public Health 6, 54 (2018).
Chorpita, B. F. et al. Long term outcomes for the child steps randomized effectiveness trial: a comparison of modular and standard treatment designs with usual care. J. Consult. Clin. Psychol. 81, 999–1009 (2013).
Cheron, D. M. et al. Assessing practical implementation of modular psychotherapy for youth in community-based settings using benchmarking. Implement. Res. Pract. 3, 26334895221115216 (2022).
Jørgensen, K., Hansen, M. & Karlsson, B. Recovery-oriented practices in a mental health centre for citizens experiencing serious mental issues and substance use: as perceived by healthcare professionals. Int. J. Environ. Res. Public Health 19, 10294 (2022).
Jørgensen, K. et al. Recovery-oriented intersectoral care in mental health: as perceived by healthcare professionals and users. Int. J. Environ. Res. Public Health 17, 8777 (2020).
Jørgensen, K. et al. Perspectives on recovery-oriented care in mental health practices: health professionals experiences. Issues Ment. Health Nurs. 44, 200–208 (2023).
Dziobek, I. et al. Die beteiligung von Betroffenen und Angehörigen am Deutschen Zentrum für Psychische Gesundheit. Nervenarzt. 93, 300–301 (2022).
Lipinski, S. et al. Patient and public involvement am Deutschen Zentrum für Psychische Gesundheit: Erreichtes und Herausforderungen. Nervenarzt 95, 458–466 (2024).
Zechmeister-Koss, I. et al. Reaching families where a parent has a mental disorder: using big data to plan early interventions. Neuropsychiatr. 34, 39–47 (2020).
West, S. G. et al. Propensity scores as a basis for equating groups: basic principles and application in clinical treatment outcome research. J. Consult. Clin. Psychol. 82, 906–919 (2014).
Acknowledgements
We wish to thank all families who participated in the projects. The study was funded by the German Federal Ministry of Education and Research (funding # 01GL1748B).
Author information
Authors and Affiliations
Contributions
E.T., M.S. and H.C. contributed to the conception of the work and wrote the initial draft of the manuscript. S.F., G.d.G., K.G., C.R., K.O., R.S., B.R., J.L.P. and A.A.E.T. critically reviewed the manuscript for intellectual content. All authors reviewed and edited subsequent drafts, and approved the final version.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Peer review
Peer review information
Nature Mental Health thanks Katharina Kircanski and the other, anonymous, reviewers for their contribution to the peer review of this work.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Supplementary Information
Supplementary Fig. 1.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Toffol, E., Stracke, M., Harlos, N. et al. Lessons on targeting family mental health and improving outcomes for children of parents with a mental illness. Nat. Mental Health 2, 893–900 (2024). https://doi.org/10.1038/s44220-024-00285-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44220-024-00285-3